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• W1914733225 abstract "One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer morbidity and mortality are largely related to the spread of the primary, localized tumour to adjacent and distant sites. Appropriate management and treatment decisions based on predicting metastatic disease at the time of diagnosis is thus crucial, which supports better understanding of the metastatic process. There are components of metastasis that are common to all primary tumours: dissociation from the primary tumour mass, reorganization/remodelling of extracellular matrix, cell migration, recognition and movement through endothelial cells and the vascular circulation and lodgement and proliferation within ectopic stroma. One of the key and initial events is the increased ability of cancer cells to move, escaping the regulation of normal physiological control. The cellular cytoskeleton plays an important role in cancer cell motility and active cytoskeletal rearrangement can result in metastatic disease. This active change in cytoskeletal dynamics results in manipulation of plasma membrane and cellular balance between cellular adhesion and motility which in turn determines cancer cell movement. Members of the tetraspanin family of proteins play important roles in regulation of cancer cell migration and cancer-endothelial cell interactions, which are critical for cancer invasion and metastasis. Their involvements in active cytoskeletal dynamics, cancer metastasis and potential clinical application will be discussed in this review. In particular, the tetraspanin member, CD151, is highlighted for its major role in cancer invasion and metastasis.This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-24." @default.
• W1914733225 created "2016-06-24" @default.
• W1914733225 creator A5003476651 @default.
• W1914733225 creator A5052143564 @default.
• W1914733225 creator A5061401133 @default.
• W1914733225 creator A5066343783 @default.
• W1914733225 date "2014-12-01" @default.
• W1914733225 modified "2023-10-14" @default.
• W1914733225 title "Tetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies" @default.
• W1914733225 cites W1491899760 @default.
• W1914733225 cites W1503680627 @default.
• W1914733225 cites W1525967044 @default.
• W1914733225 cites W1547518268 @default.
• W1914733225 cites W1555648778 @default.
• W1914733225 cites W1573363574 @default.
• W1914733225 cites W1581670892 @default.
• W1914733225 cites W1586824865 @default.
• W1914733225 cites W1591179447 @default.
• W1914733225 cites W1592294264 @default.
• W1914733225 cites W1595810968 @default.
• W1914733225 cites W1599923672 @default.
• W1914733225 cites W1622444552 @default.
• W1914733225 cites W1665767818 @default.
• W1914733225 cites W1757796572 @default.
• W1914733225 cites W1762620449 @default.
• W1914733225 cites W1874379912 @default.
• W1914733225 cites W1875087350 @default.
• W1914733225 cites W1889489351 @default.
• W1914733225 cites W1900346306 @default.
• W1914733225 cites W1924064381 @default.
• W1914733225 cites W1947723185 @default.
• W1914733225 cites W1963560969 @default.
• W1914733225 cites W1964287760 @default.
• W1914733225 cites W1964915114 @default.
• W1914733225 cites W1965512756 @default.
• W1914733225 cites W1966297372 @default.
• W1914733225 cites W1966603878 @default.
• W1914733225 cites W1966752271 @default.
• W1914733225 cites W1966995226 @default.
• W1914733225 cites W1967266747 @default.
• W1914733225 cites W1967427925 @default.
• W1914733225 cites W1967484155 @default.
• W1914733225 cites W1969738372 @default.
• W1914733225 cites W1969986893 @default.
• W1914733225 cites W1970858060 @default.
• W1914733225 cites W1971874657 @default.
• W1914733225 cites W1972192748 @default.
• W1914733225 cites W1973335196 @default.
• W1914733225 cites W1974045722 @default.
• W1914733225 cites W1974323796 @default.
• W1914733225 cites W1975959933 @default.
• W1914733225 cites W1977037952 @default.
• W1914733225 cites W1978806870 @default.
• W1914733225 cites W1979973591 @default.
• W1914733225 cites W1980273990 @default.
• W1914733225 cites W1981373172 @default.
• W1914733225 cites W1981803446 @default.
• W1914733225 cites W1981862901 @default.
• W1914733225 cites W1983947761 @default.
• W1914733225 cites W1985778136 @default.
• W1914733225 cites W1985831769 @default.
• W1914733225 cites W1986218383 @default.
• W1914733225 cites W1987242333 @default.
• W1914733225 cites W1987262484 @default.
• W1914733225 cites W1989097613 @default.
• W1914733225 cites W1989861712 @default.
• W1914733225 cites W1990922679 @default.
• W1914733225 cites W1991923672 @default.
• W1914733225 cites W1993247439 @default.
• W1914733225 cites W1993650879 @default.
• W1914733225 cites W1994506188 @default.
• W1914733225 cites W1994640931 @default.
• W1914733225 cites W1995119812 @default.
• W1914733225 cites W1995627894 @default.
• W1914733225 cites W1995941191 @default.
• W1914733225 cites W1996340555 @default.
• W1914733225 cites W1997045968 @default.
• W1914733225 cites W1997580724 @default.
• W1914733225 cites W1999576341 @default.
• W1914733225 cites W1999937407 @default.
• W1914733225 cites W2000515943 @default.
• W1914733225 cites W2001212328 @default.
• W1914733225 cites W2001339111 @default.
• W1914733225 cites W2001497601 @default.
• W1914733225 cites W2001639569 @default.
• W1914733225 cites W2002450099 @default.
• W1914733225 cites W2002942039 @default.
• W1914733225 cites W2003404530 @default.
• W1914733225 cites W2003431167 @default.
• W1914733225 cites W2003454386 @default.
• W1914733225 cites W2004173014 @default.
• W1914733225 cites W2004884265 @default.
• W1914733225 cites W2007446347 @default.
• W1914733225 cites W2013289215 @default.
• W1914733225 cites W2013480667 @default.
• W1914733225 cites W2014276215 @default.
• W1914733225 cites W2017306734 @default.
• W1914733225 cites W2017767253 @default.

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