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• W1914940661 endingPage "2240" @default.
• W1914940661 startingPage "2233" @default.
• W1914940661 abstract "ABSTRACT Type IV neuronal intermediate filament proteins consist of α-internexin, which can self-assemble into filaments and the neurofilament triplet proteins, which are obligate heteropolymers, at least in rodents. These IF proteins therefore provide good systems for elucidating the mechanism of intermediate filament assembly. To analyze the roles of the head domains of these proteins in contributing to their differential assembly properties, we generated chimeric proteins by swapping the head domains between rat α-internexin and either rat NF-L or NF-M and examined their assembly properties in transfected cells that lack their own cytoplasmic intermediate filament network. Lαα and Mαα, the chimeric proteins generated by replacing the head domain of α-internexin with those of NF-L and NF-M, respectively, were unable to self-assemble into filaments. In contrast, αLL, a chimeric NF-L protein generated by replacing the head domain of NF-L with that of α-internexin, was able to self-assemble into filaments, whereas MLL, a chimeric NF-L protein containing the NF-M head domain, was unable to do so. These results demonstrate that the α-internexin head domain is essential for α-internexin’s ability to self-assemble. While coassembly of Lαα with NF-M and coassembly of Mαα with NF-L resulted in formation of filaments, coassembly of Lαα with NF-L and coassembly of Mαα with NF-M yielded punctate patterns. These coassembly results show that heteropolymeric filament formation requires that one partner has the NF-L head domain and the other partner has the NF-M head domain. Thus, the head domains of rat NF-L and NF-M play important roles in determining the obligate heteropolymeric nature of filament formation. The data obtained from these self-assembly and coassembly studies provide some new insights into the mechanism of intermediate filament assembly." @default.
• W1914940661 created "2016-06-24" @default.
• W1914940661 creator A5005034015 @default.
• W1914940661 creator A5015810346 @default.
• W1914940661 date "1999-07-01" @default.
• W1914940661 modified "2023-10-13" @default.
• W1914940661 title "Analysis of the roles of the head domains of type IV rat neuronal intermediate filament proteins in filament assembly using domain-swapped chimeric proteins" @default.
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• W1914940661 doi "https://doi.org/10.1242/jcs.112.13.2233" @default.
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