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• W1915055765 startingPage "282" @default.
• W1915055765 abstract "In eukaryotes, CpG methylation is an epigenetic DNA modification that is important for heterochromatin formation. Centromere protein B (CENP-B) specifically binds to the centromeric 17 base-pair CENP-B box DNA, which contains two CpG dinucleotides. In this study, we tested complex formation by the DNA-binding domain of CENP-B with methylated and unmethylated CENP-B box DNAs, and found that CENP-B preferentially binds to the unmethylated CENP-B box DNA. Competition analyses revealed that the affinity of CENP-B for the CENP-B box DNA is reduced nearly to the level of nonspecific DNA binding by CpG methylation." @default.
• W1915055765 created "2016-06-24" @default.
• W1915055765 creator A5016892353 @default.
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• W1915055765 creator A5076829080 @default.
• W1915055765 date "2004-12-02" @default.
• W1915055765 modified "2023-10-02" @default.
• W1915055765 title "CpG methylation of the CENP-B box reduces human CENP-B binding" @default.
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• W1915055765 doi "https://doi.org/10.1111/j.1432-1033.2004.04406.x" @default.
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• W1915055765 hasPublicationYear "2004" @default.
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