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- W19150834 abstract "Publisher Summary This chapter discusses the polymorphism of H-2 antigens in wild mice from the United States and various parts of Europe and the Near East. These serological typing studies have answered many questions about H-2 polymorphism and also have revealed new factors about the dynamics of the polymorphism, which are yet to be explained. Genes in the H-2 complex control the expression of cell surface glycoproteins and can be divided into two classes on the basis of their functions in the immune system. The class I molecules (products of the H-2K and H-2D loci) are directly involved in the differentiation and activation of cytotoxic T cells that recognize and destroy virus-infected cells. The polymorphism of MHC genes can be viewed as a direct result of their functions in the recognition of antigens by the immune system. The deficiencies in immune responsiveness that are associated with specific MHC alleles reflect the unique abilities of MHC polymorphisms to moderate T-cell activation by antigens. This property is advantageous in two ways. First, MHC genes represent a focal point for selective pressures affecting immune responsiveness. The sensitivity of immune responsiveness to genetic variations in MHC genes provides a mechanism by which the immune system can rapidly adapt to the specific selective pressures of endemic pathogens. Second, the coevolution of these genes with the antigenicity of the endemic pathogens may result in a stable MHC polymorphism which facilitates the evolution of low virulence pathogens. The Ir defects of the most common MHC phenotypes may allow infections predominantly by endemic pathogens, which do not normally cause serious clinical diseases." @default.
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- W19150834 modified "2023-09-27" @default.
- W19150834 title "IMMUNE RESPONSIVENESS AND POLYMORPHISM OF THE MAJOR HISTOCOMPATIBILITY COMPLEX: AN INTERPRETATION" @default.
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- W19150834 doi "https://doi.org/10.1016/b978-0-12-637140-6.50016-4" @default.
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