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- W1915103654 abstract "We studied the reparative process after inhalation exposure to 20 ppm of nitrogen dioxide (NO2) in the lungs of hemizygous blotchy male (Blo/y) and heterozygous blotchy female (Blo/+) mice. Age-matched siblings (C3Hf) without the blotchy gene at X-chromosome locus (+/y and +/+) served as control animals. After exposure to NO2 for 28 days, there was a marked progression in the extent of emphysema in Blo/y mice associated with a significant decrease of internal surface area (p 0.005). In contrast, +/y, Blo/+, and +/+ mice showed mild airspace enlargement without decrease in internal surface area after similar exposures. Blo/y mice killed 1 month after cessation of NO2 exposure showed a persistent, mild chronic bronchiolitis that was more frequent and of greater severity than that present in control +/y mice. Alveolar macrophages in the Blo/y mice were larger than those in +/y, +/+, and Blo/+ mice both before and after exposure to NO2. Crystalloid inc..." @default.
- W1915103654 created "2016-06-24" @default.
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- W1915103654 date "2015-05-14" @default.
- W1915103654 modified "2023-09-24" @default.
- W1915103654 title "Lung Injury and Repair in the Blotchy Mouse" @default.
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