Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915178910> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1915178910 endingPage "489" @default.
- W1915178910 startingPage "481" @default.
- W1915178910 abstract "Thechain-breaking antioxidant activities of reduced form of novel type ofgeroprotectors, mitochondria-targeted quinones (QH2) havequantitatively been measured for the first time. To this end, the chainperoxidation of methyl linoleate (ML) in Triton micelles was used as akinetic testing model. The studied QH2 were lipophilictriphenylphosphonium cations conjugated by an aliphatic linker to anantioxidant, i.e. a ubiquinol moiety (MitoQH2) or plastoquinolmoiety (SkQH2). The antioxidant activity was characterized bythe rate constant k1 for the reaction between QH2 andthe lipid peroxyl radical (LO2·) originatedfrom ML: QH2 + LO2· â HQ· + LOOH. Allthe tested QH2 displayed a pronounced antioxidant activity. Theoxidized forms of the same compounds did not inhibit ML peroxidation. Thevalue of k1 for SkQH2 far exceeded k1 forMitoQH2. For the biologically active geroprotectors SkQ1H2,the k1 value found to be as high as 2.2 à 105 M-1s-1,whereas for MitoQH2, it was 0.58 à 105 M-1s-1. The kineticbehavior of QH2 suggested that SkQ1H2 can rathereasily diffuse through lipid-water microheterogeneous systems." @default.
- W1915178910 created "2016-06-24" @default.
- W1915178910 creator A5021100324 @default.
- W1915178910 creator A5048699812 @default.
- W1915178910 creator A5063639723 @default.
- W1915178910 date "2009-05-12" @default.
- W1915178910 modified "2023-09-26" @default.
- W1915178910 title "Chain-breaking antioxidant activity of reduced forms ofmitochondria-targeted quinones, a novel type of geroprotectors" @default.
- W1915178910 cites W1992714575 @default.
- W1915178910 cites W1993443407 @default.
- W1915178910 cites W2013970530 @default.
- W1915178910 cites W2062370665 @default.
- W1915178910 cites W2133148204 @default.
- W1915178910 cites W2162248789 @default.
- W1915178910 cites W2206183556 @default.
- W1915178910 cites W639160051 @default.
- W1915178910 doi "https://doi.org/10.18632/aging.100049" @default.
- W1915178910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2830047" @default.
- W1915178910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20195487" @default.
- W1915178910 hasPublicationYear "2009" @default.
- W1915178910 type Work @default.
- W1915178910 sameAs 1915178910 @default.
- W1915178910 citedByCount "26" @default.
- W1915178910 countsByYear W19151789102012 @default.
- W1915178910 countsByYear W19151789102013 @default.
- W1915178910 countsByYear W19151789102014 @default.
- W1915178910 countsByYear W19151789102016 @default.
- W1915178910 countsByYear W19151789102017 @default.
- W1915178910 countsByYear W19151789102018 @default.
- W1915178910 countsByYear W19151789102020 @default.
- W1915178910 countsByYear W19151789102022 @default.
- W1915178910 crossrefType "journal-article" @default.
- W1915178910 hasAuthorship W1915178910A5021100324 @default.
- W1915178910 hasAuthorship W1915178910A5048699812 @default.
- W1915178910 hasAuthorship W1915178910A5063639723 @default.
- W1915178910 hasBestOaLocation W19151789101 @default.
- W1915178910 hasConcept C112613896 @default.
- W1915178910 hasConcept C14471203 @default.
- W1915178910 hasConcept C155647269 @default.
- W1915178910 hasConcept C178790620 @default.
- W1915178910 hasConcept C185592680 @default.
- W1915178910 hasConcept C2776568683 @default.
- W1915178910 hasConcept C2778004101 @default.
- W1915178910 hasConcept C2778777121 @default.
- W1915178910 hasConcept C28859421 @default.
- W1915178910 hasConcept C29311851 @default.
- W1915178910 hasConcept C521977710 @default.
- W1915178910 hasConcept C55493867 @default.
- W1915178910 hasConcept C71240020 @default.
- W1915178910 hasConceptScore W1915178910C112613896 @default.
- W1915178910 hasConceptScore W1915178910C14471203 @default.
- W1915178910 hasConceptScore W1915178910C155647269 @default.
- W1915178910 hasConceptScore W1915178910C178790620 @default.
- W1915178910 hasConceptScore W1915178910C185592680 @default.
- W1915178910 hasConceptScore W1915178910C2776568683 @default.
- W1915178910 hasConceptScore W1915178910C2778004101 @default.
- W1915178910 hasConceptScore W1915178910C2778777121 @default.
- W1915178910 hasConceptScore W1915178910C28859421 @default.
- W1915178910 hasConceptScore W1915178910C29311851 @default.
- W1915178910 hasConceptScore W1915178910C521977710 @default.
- W1915178910 hasConceptScore W1915178910C55493867 @default.
- W1915178910 hasConceptScore W1915178910C71240020 @default.
- W1915178910 hasIssue "5" @default.
- W1915178910 hasLocation W19151789101 @default.
- W1915178910 hasLocation W19151789102 @default.
- W1915178910 hasLocation W19151789103 @default.
- W1915178910 hasLocation W19151789104 @default.
- W1915178910 hasOpenAccess W1915178910 @default.
- W1915178910 hasPrimaryLocation W19151789101 @default.
- W1915178910 hasRelatedWork W1941065515 @default.
- W1915178910 hasRelatedWork W1969628253 @default.
- W1915178910 hasRelatedWork W2042632977 @default.
- W1915178910 hasRelatedWork W2074695893 @default.
- W1915178910 hasRelatedWork W2088444332 @default.
- W1915178910 hasRelatedWork W2108643578 @default.
- W1915178910 hasRelatedWork W2189399242 @default.
- W1915178910 hasRelatedWork W2238555127 @default.
- W1915178910 hasRelatedWork W2770624555 @default.
- W1915178910 hasRelatedWork W2890760102 @default.
- W1915178910 hasVolume "1" @default.
- W1915178910 isParatext "false" @default.
- W1915178910 isRetracted "false" @default.
- W1915178910 magId "1915178910" @default.
- W1915178910 workType "article" @default.