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- W1915192275 abstract "We injected a combination of the β-amyloids (Aβs) Aβ40 and Aβ43 to “seed” formation of amyloid deposits in the dorsal dentate gyrus of rats <i>in vivo</i>, on the basis of a theory of Jarrett and Landsbury (1993). Rats were tested on several different learning tasks, and synaptic transmission and plasticity were assessed<i>in vivo</i>. Between 7 and 16 weeks after injection, we found aggregated amyloid material, reactive astrocytosis, microgliosis, and cell loss around the sites of injection. Rats were impaired specifically in working memory type tasks in accordance with the type of memory deficit observed in the early stages of Alzheimer9s disease. Synaptic transmission and long-term potentiation, a candidate cellular mechanism for memory, were severely impaired <i>in vivo</i>. Injections of the same dose of fragments individually did not induce these effects. These findings suggest that aggregated amyloid material induces cognitive deficits similar to those observed in the early phases of Alzheimer9s disease via an alteration in neuronal transmission and plasticity." @default.
- W1915192275 created "2016-06-24" @default.
- W1915192275 creator A5023828819 @default.
- W1915192275 creator A5039247811 @default.
- W1915192275 creator A5066433828 @default.
- W1915192275 date "2001-08-01" @default.
- W1915192275 modified "2023-09-26" @default.
- W1915192275 title "Generation of Aggregated β-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits" @default.
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- W1915192275 doi "https://doi.org/10.1523/jneurosci.21-15-05703.2001" @default.
- W1915192275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762634" @default.
- W1915192275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11466442" @default.
- W1915192275 hasPublicationYear "2001" @default.
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