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• W1915200775 abstract "Abstract Cardiac valves serve an important function; they support unidirectional blood flow and prevent blood regurgitation. Wnt signaling plays an important role in the formation of mouse cardiac valves and cardiac valve proliferation in Zebrafish, but identification of the specific signaling components involved has not been addressed systematically. Of the components involved in Wnt signal transduction, pygopus ( pygo ), first identified as a core component of Wnt signaling in Drosophila , has not yet to be investigated with respect to valve development and differentiation. Here, we take advantage of the Drosophila heart model to study the role of pygo in formation of valves between the cardiac chambers. We found that cardiac‐specific pygo knockdown in the Drosophila heart causes dilation in the region of these cardiac valves, and their characteristic dense mesh of myofibrils does not form and resembles that of neighboring cardiomyocytes. In contrast, heart‐specific knockdown of the transcription factors, arm/β‐Cat, lgs/BCL9 , or pan/TCF , which mediates canonical Wnt signal transduction, shows a much weaker valve differentiation defect. Double‐heterozygous combinations of mutants for pygo and the Wnt‐signaling components have no additional effect on heart function compared with pygo heterozygotes alone. These results are consistent with the idea that pygo functions independently of canonical Wnt signaling in the differentiation of the adult interchamber cardiac valves. genesis 52:19–28, 2014. © 2013 Wiley Periodicals, Inc." @default.
• W1915200775 created "2016-06-24" @default.
• W1915200775 creator A5014149946 @default.
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• W1915200775 date "2013-11-21" @default.
• W1915200775 modified "2023-10-07" @default.
• W1915200775 title "The role of<i>Pygopus</i>in the differentiation of intracardiac valves in<i>Drosophila</i>" @default.
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• W1915200775 doi "https://doi.org/10.1002/dvg.22724" @default.
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