FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915207767> ?p ?o ?g. }

• W1915207767 endingPage "2531" @default.
• W1915207767 startingPage "2525" @default.
• W1915207767 abstract "It has been hypothesized that high concentrations of tissue iron may enhance carcinogenesis induced by free radical mechanisms. Wy-14,643 is a peroxisome proliferator that is hepatocarcinogenic in rats. Tumor induction may result in part from excessive production of reactive oxygen species, particularly H2O2. The purpose of this study was to examine the effect of iron status on oxidative stress and NF-κB activation in livers of rats treated with Wy-14,643. Forty-eight male Sprague–Dawley rats were fed one of four diets (20, 45, 650, 1500 mg Fe/kg diet) for 28 d. At the time of tissue collection, liver iron ranged from 1.4 to 9.9 μmol/g wet tissue in the diet groups. Wy-14,643 (0 or 0.1 g/100 g diet) was added to the diet for the final 10 d of the study. Wy-14,643 doubled the liver weight/body weight ratio (P = 0.0001), which was also increased by iron supplementation (P < 0.01). Iron supplementation increased thiobarbituric acid reactive substances and/or conjugated dienes, but there was no synergism between Wy 14,643 and iron on lipid peroxidation measures. The hepatic DNA binding activity of NF-κB was increased in rats administered Wy-14,643. However, differences in liver iron concentration did not alter activation of NF-κB in untreated rats or in those treated with Wy-14,643. DNA double-strand breakage was not affected by iron or Wy-14,643. In summary, although moderate changes in iron status altered liver lipid peroxidation, iron did not significantly increase oxidative stress induced by a hepatocarcinogenic peroxisome proliferator." @default.
• W1915207767 created "2016-06-24" @default.
• W1915207767 creator A5015532394 @default.
• W1915207767 creator A5017952738 @default.
• W1915207767 creator A5041469650 @default.
• W1915207767 creator A5073805846 @default.
• W1915207767 creator A5083825216 @default.
• W1915207767 creator A5088213444 @default.
• W1915207767 date "2002-09-01" @default.
• W1915207767 modified "2023-10-03" @default.
• W1915207767 title "Moderate Iron Overload Enhances Lipid Peroxidation in Livers of Rats, but Does Not Affect NF-κB Activation Induced by the Peroxisome Proliferator, Wy-14,643" @default.
• W1915207767 cites W1564688274 @default.
• W1915207767 cites W1590457525 @default.
• W1915207767 cites W1607711282 @default.
• W1915207767 cites W1775749144 @default.
• W1915207767 cites W1831301545 @default.
• W1915207767 cites W1978601099 @default.
• W1915207767 cites W1991880580 @default.
• W1915207767 cites W2001223353 @default.
• W1915207767 cites W2031643961 @default.
• W1915207767 cites W2032923829 @default.
• W1915207767 cites W2034684849 @default.
• W1915207767 cites W2035386076 @default.
• W1915207767 cites W2048086807 @default.
• W1915207767 cites W2056828451 @default.
• W1915207767 cites W2058780695 @default.
• W1915207767 cites W2059418320 @default.
• W1915207767 cites W2078319346 @default.
• W1915207767 cites W2084774843 @default.
• W1915207767 cites W2089554119 @default.
• W1915207767 cites W2089660317 @default.
• W1915207767 cites W2105663099 @default.
• W1915207767 cites W2108859117 @default.
• W1915207767 cites W2114073954 @default.
• W1915207767 cites W2115110047 @default.
• W1915207767 cites W2134392069 @default.
• W1915207767 cites W2141304288 @default.
• W1915207767 cites W2145773977 @default.
• W1915207767 cites W2154225245 @default.
• W1915207767 cites W2168109557 @default.
• W1915207767 cites W2175174083 @default.
• W1915207767 doi "https://doi.org/10.1093/jn/132.9.2525" @default.
• W1915207767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12221204" @default.
• W1915207767 hasPublicationYear "2002" @default.
• W1915207767 type Work @default.
• W1915207767 sameAs 1915207767 @default.
• W1915207767 citedByCount "46" @default.
• W1915207767 countsByYear W19152077672012 @default.
• W1915207767 countsByYear W19152077672013 @default.
• W1915207767 countsByYear W19152077672014 @default.
• W1915207767 countsByYear W19152077672016 @default.
• W1915207767 countsByYear W19152077672017 @default.
• W1915207767 countsByYear W19152077672019 @default.
• W1915207767 countsByYear W19152077672020 @default.
• W1915207767 countsByYear W19152077672021 @default.
• W1915207767 crossrefType "journal-article" @default.
• W1915207767 hasAuthorship W1915207767A5015532394 @default.
• W1915207767 hasAuthorship W1915207767A5017952738 @default.
• W1915207767 hasAuthorship W1915207767A5041469650 @default.
• W1915207767 hasAuthorship W1915207767A5073805846 @default.
• W1915207767 hasAuthorship W1915207767A5083825216 @default.
• W1915207767 hasAuthorship W1915207767A5088213444 @default.
• W1915207767 hasBestOaLocation W19152077671 @default.
• W1915207767 hasConcept C126322002 @default.
• W1915207767 hasConcept C134018914 @default.
• W1915207767 hasConcept C185592680 @default.
• W1915207767 hasConcept C2776151105 @default.
• W1915207767 hasConcept C2780829032 @default.
• W1915207767 hasConcept C48349386 @default.
• W1915207767 hasConcept C55493867 @default.
• W1915207767 hasConcept C71924100 @default.
• W1915207767 hasConcept C86803240 @default.
• W1915207767 hasConceptScore W1915207767C126322002 @default.
• W1915207767 hasConceptScore W1915207767C134018914 @default.
• W1915207767 hasConceptScore W1915207767C185592680 @default.
• W1915207767 hasConceptScore W1915207767C2776151105 @default.
• W1915207767 hasConceptScore W1915207767C2780829032 @default.
• W1915207767 hasConceptScore W1915207767C48349386 @default.
• W1915207767 hasConceptScore W1915207767C55493867 @default.
• W1915207767 hasConceptScore W1915207767C71924100 @default.
• W1915207767 hasConceptScore W1915207767C86803240 @default.
• W1915207767 hasIssue "9" @default.
• W1915207767 hasLocation W19152077671 @default.
• W1915207767 hasLocation W19152077672 @default.
• W1915207767 hasOpenAccess W1915207767 @default.
• W1915207767 hasPrimaryLocation W19152077671 @default.
• W1915207767 hasRelatedWork W1470000624 @default.
• W1915207767 hasRelatedWork W1966211672 @default.
• W1915207767 hasRelatedWork W1969075951 @default.
• W1915207767 hasRelatedWork W1972397386 @default.
• W1915207767 hasRelatedWork W2335044792 @default.
• W1915207767 hasRelatedWork W2400395252 @default.
• W1915207767 hasRelatedWork W2463643859 @default.
• W1915207767 hasRelatedWork W2507419442 @default.
• W1915207767 hasRelatedWork W2748952813 @default.
• W1915207767 hasRelatedWork W4285310363 @default.
• W1915207767 hasVolume "132" @default.
• W1915207767 isParatext "false" @default.

• next