FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915207889> ?p ?o ?g. }

• W1915207889 abstract "Anti-hepatitis C virus (HCV) responses are often accompanied by an increase in alanine aminotransferase levels in HCV-infected patients, indicating that inflammatory responses are compromised by the virus. Additionally, inflammation is associated with M1-polarizated macrophages, which secrete cytokines such as tumor necrosis factor-α, interleukin-1, and interleukin-12, and present antigens through phagocytosis. HCV-encoded proteins are presented as specific viral antigens in particular infectious steps that influence the immune response. For instance, HCV antigens impact macrophage PD-1 and Tim-3 expression, and contribute to impaired viral clearance. Furthermore, circulatory HCV antigens from infected patients inhibit dendritic cell differentiation, which raises the possibility that HCV antigens may also interfere with macrophage polarization. In this study, the impact of HCV antigen stimulation on M1-polarized macrophages was investigated. The influence of HCV antigens was evaluated by reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Specific changes were investigated clinically by flow cytometry and immunofluorescence. Effects of NF-κB during the process were analyzed by western blot. HCV infection dampened M1 macrophage polarization ex vivo and in vitro. After antigen stimulation, NF-κB signaling was suppressed by the up-regulation of A20 and A20-binding inhibitor of NF-κB binding protein, which likely leads to a variation of functional molecules such as tumor necrosis factor-α, CD163, matrix metalloproteinases, transferrin receptor-1, and CD100, reflecting an anti-inflammatory reaction against M1-polarization. HCV antigens stimulation up-regulates A20/A20-binding inhibitor of NF-κB binding protein expression, which consequently contributes to inefficient M1 macrophage polarization." @default.
• W1915207889 created "2016-06-24" @default.
• W1915207889 creator A5013415135 @default.
• W1915207889 creator A5014978298 @default.
• W1915207889 creator A5023437483 @default.
• W1915207889 creator A5039636798 @default.
• W1915207889 creator A5046960094 @default.
• W1915207889 creator A5064038450 @default.
• W1915207889 creator A5087167187 @default.
• W1915207889 date "2015-09-17" @default.
• W1915207889 modified "2023-09-23" @default.
• W1915207889 title "Up-regulation of A20/ABIN1 contributes to inefficient M1 macrophage polarization during Hepatitis C virus infection" @default.
• W1915207889 cites W1411966751 @default.
• W1915207889 cites W1548584275 @default.
• W1915207889 cites W1562804387 @default.
• W1915207889 cites W1585906932 @default.
• W1915207889 cites W1743492246 @default.
• W1915207889 cites W1821034349 @default.
• W1915207889 cites W1834782762 @default.
• W1915207889 cites W1925993589 @default.
• W1915207889 cites W1965544877 @default.
• W1915207889 cites W1965696997 @default.
• W1915207889 cites W1967369695 @default.
• W1915207889 cites W1968906374 @default.
• W1915207889 cites W1971752166 @default.
• W1915207889 cites W1972348350 @default.
• W1915207889 cites W1975752601 @default.
• W1915207889 cites W1978946907 @default.
• W1915207889 cites W1983015423 @default.
• W1915207889 cites W1985502949 @default.
• W1915207889 cites W1988650954 @default.
• W1915207889 cites W1991899045 @default.
• W1915207889 cites W1993197717 @default.
• W1915207889 cites W1995158734 @default.
• W1915207889 cites W1998525935 @default.
• W1915207889 cites W2002516194 @default.
• W1915207889 cites W2014752961 @default.
• W1915207889 cites W2015445169 @default.
• W1915207889 cites W2015769702 @default.
• W1915207889 cites W2015863483 @default.
• W1915207889 cites W2021245470 @default.
• W1915207889 cites W2032864901 @default.
• W1915207889 cites W2033970156 @default.
• W1915207889 cites W2055155827 @default.
• W1915207889 cites W2055785130 @default.
• W1915207889 cites W2064081167 @default.
• W1915207889 cites W2065210647 @default.
• W1915207889 cites W2067773277 @default.
• W1915207889 cites W2070855360 @default.
• W1915207889 cites W2074073255 @default.
• W1915207889 cites W2082695573 @default.
• W1915207889 cites W2084231086 @default.
• W1915207889 cites W2085293124 @default.
• W1915207889 cites W2092582397 @default.
• W1915207889 cites W2096559226 @default.
• W1915207889 cites W2098895683 @default.
• W1915207889 cites W2104688763 @default.
• W1915207889 cites W2105110741 @default.
• W1915207889 cites W2105428810 @default.
• W1915207889 cites W2106791445 @default.
• W1915207889 cites W2118888785 @default.
• W1915207889 cites W2121381066 @default.
• W1915207889 cites W2126812651 @default.
• W1915207889 cites W2128435884 @default.
• W1915207889 cites W2131039277 @default.
• W1915207889 cites W2133516902 @default.
• W1915207889 cites W2133536768 @default.
• W1915207889 cites W2135703618 @default.
• W1915207889 cites W2140913323 @default.
• W1915207889 cites W2144002025 @default.
• W1915207889 cites W2148044949 @default.
• W1915207889 cites W2153765164 @default.
• W1915207889 cites W2153932008 @default.
• W1915207889 cites W2157268533 @default.
• W1915207889 cites W2157650174 @default.
• W1915207889 cites W2160298674 @default.
• W1915207889 cites W2170621724 @default.
• W1915207889 doi "https://doi.org/10.1186/s12985-015-0379-0" @default.
• W1915207889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4574525" @default.
• W1915207889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26382585" @default.
• W1915207889 hasPublicationYear "2015" @default.
• W1915207889 type Work @default.
• W1915207889 sameAs 1915207889 @default.
• W1915207889 citedByCount "15" @default.
• W1915207889 countsByYear W19152078892016 @default.
• W1915207889 countsByYear W19152078892017 @default.
• W1915207889 countsByYear W19152078892019 @default.
• W1915207889 countsByYear W19152078892020 @default.
• W1915207889 countsByYear W19152078892021 @default.
• W1915207889 crossrefType "journal-article" @default.
• W1915207889 hasAuthorship W1915207889A5013415135 @default.
• W1915207889 hasAuthorship W1915207889A5014978298 @default.
• W1915207889 hasAuthorship W1915207889A5023437483 @default.
• W1915207889 hasAuthorship W1915207889A5039636798 @default.
• W1915207889 hasAuthorship W1915207889A5046960094 @default.
• W1915207889 hasAuthorship W1915207889A5064038450 @default.
• W1915207889 hasAuthorship W1915207889A5087167187 @default.
• W1915207889 hasBestOaLocation W19152078891 @default.
• W1915207889 hasConcept C147483822 @default.
• W1915207889 hasConcept C159047783 @default.

• next