FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915221427> ?p ?o ?g. }

• W1915221427 endingPage "3101" @default.
• W1915221427 startingPage "3095" @default.
• W1915221427 abstract "A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human vaccine strain) and JE Nakayama (JE-N [virulent mouse brain-passaged strain]), were studied in cell culture and laboratory mice. The JE envelope protein (E) retained antigenic and biological properties when expressed with its prM protein together with the YF capsid; however, viable chimeric viruses incorporating the entire JE structural region (C-prM-E) could not be obtained. YF/JE(prM-E) chimeric viruses grew efficiently in cells of vertebrate or mosquito origin compared to the parental viruses. The YF/JE SA14-14-2 virus was unable to kill young adult mice by intracerebral challenge, even at doses of 10(6) PFU. In contrast, the YF/JE-N virus was neurovirulent, but the phenotype resembled parental YF virus rather than JE-N. Ten predicted amino acid differences distinguish the JE E proteins of the two chimeric viruses, therefore implicating one or more residues as virus-specific determinants of mouse neurovirulence in this chimeric system. This study indicates the feasibility of expressing protective antigens of JE virus in the context of a live, attenuated flavivirus vaccine strain (YF17D) and also establishes a genetic system for investigating the molecular basis for neurovirulence determinants encoded within the JE E protein." @default.
• W1915221427 created "2016-06-24" @default.
• W1915221427 creator A5019683467 @default.
• W1915221427 creator A5024293644 @default.
• W1915221427 creator A5062705485 @default.
• W1915221427 creator A5069627008 @default.
• W1915221427 date "1999-04-01" @default.
• W1915221427 modified "2023-10-14" @default.
• W1915221427 title "Yellow Fever/Japanese Encephalitis Chimeric Viruses: Construction and Biological Properties" @default.
• W1915221427 cites W1830896867 @default.
• W1915221427 cites W1967083901 @default.
• W1915221427 cites W1967826883 @default.
• W1915221427 cites W1970057644 @default.
• W1915221427 cites W1970455211 @default.
• W1915221427 cites W1973123733 @default.
• W1915221427 cites W1975244602 @default.
• W1915221427 cites W1982090618 @default.
• W1915221427 cites W1996987325 @default.
• W1915221427 cites W2031554814 @default.
• W1915221427 cites W2038891761 @default.
• W1915221427 cites W2046997318 @default.
• W1915221427 cites W2061537187 @default.
• W1915221427 cites W2069040057 @default.
• W1915221427 cites W2072190572 @default.
• W1915221427 cites W2072897393 @default.
• W1915221427 cites W2081383601 @default.
• W1915221427 cites W2135004444 @default.
• W1915221427 cites W2140036976 @default.
• W1915221427 cites W2147232300 @default.
• W1915221427 cites W2161387440 @default.
• W1915221427 cites W2163412375 @default.
• W1915221427 cites W2175522297 @default.
• W1915221427 cites W966480989 @default.
• W1915221427 doi "https://doi.org/10.1128/jvi.73.4.3095-3101.1999" @default.
• W1915221427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/104070" @default.
• W1915221427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10074160" @default.
• W1915221427 hasPublicationYear "1999" @default.
• W1915221427 type Work @default.
• W1915221427 sameAs 1915221427 @default.
• W1915221427 citedByCount "238" @default.
• W1915221427 countsByYear W19152214272012 @default.
• W1915221427 countsByYear W19152214272013 @default.
• W1915221427 countsByYear W19152214272014 @default.
• W1915221427 countsByYear W19152214272015 @default.
• W1915221427 countsByYear W19152214272016 @default.
• W1915221427 countsByYear W19152214272017 @default.
• W1915221427 countsByYear W19152214272018 @default.
• W1915221427 countsByYear W19152214272019 @default.
• W1915221427 countsByYear W19152214272020 @default.
• W1915221427 countsByYear W19152214272021 @default.
• W1915221427 countsByYear W19152214272022 @default.
• W1915221427 countsByYear W19152214272023 @default.
• W1915221427 crossrefType "journal-article" @default.
• W1915221427 hasAuthorship W1915221427A5019683467 @default.
• W1915221427 hasAuthorship W1915221427A5024293644 @default.
• W1915221427 hasAuthorship W1915221427A5062705485 @default.
• W1915221427 hasAuthorship W1915221427A5069627008 @default.
• W1915221427 hasBestOaLocation W19152214271 @default.
• W1915221427 hasConcept C104317684 @default.
• W1915221427 hasConcept C123894998 @default.
• W1915221427 hasConcept C143065580 @default.
• W1915221427 hasConcept C151730666 @default.
• W1915221427 hasConcept C159047783 @default.
• W1915221427 hasConcept C202878990 @default.
• W1915221427 hasConcept C2522874641 @default.
• W1915221427 hasConcept C25365240 @default.
• W1915221427 hasConcept C2777510210 @default.
• W1915221427 hasConcept C2779131611 @default.
• W1915221427 hasConcept C2779141303 @default.
• W1915221427 hasConcept C2779343474 @default.
• W1915221427 hasConcept C2780568436 @default.
• W1915221427 hasConcept C2780727368 @default.
• W1915221427 hasConcept C40767141 @default.
• W1915221427 hasConcept C54355233 @default.
• W1915221427 hasConcept C83455156 @default.
• W1915221427 hasConcept C86803240 @default.
• W1915221427 hasConcept C97380033 @default.
• W1915221427 hasConceptScore W1915221427C104317684 @default.
• W1915221427 hasConceptScore W1915221427C123894998 @default.
• W1915221427 hasConceptScore W1915221427C143065580 @default.
• W1915221427 hasConceptScore W1915221427C151730666 @default.
• W1915221427 hasConceptScore W1915221427C159047783 @default.
• W1915221427 hasConceptScore W1915221427C202878990 @default.
• W1915221427 hasConceptScore W1915221427C2522874641 @default.
• W1915221427 hasConceptScore W1915221427C25365240 @default.
• W1915221427 hasConceptScore W1915221427C2777510210 @default.
• W1915221427 hasConceptScore W1915221427C2779131611 @default.
• W1915221427 hasConceptScore W1915221427C2779141303 @default.
• W1915221427 hasConceptScore W1915221427C2779343474 @default.
• W1915221427 hasConceptScore W1915221427C2780568436 @default.
• W1915221427 hasConceptScore W1915221427C2780727368 @default.
• W1915221427 hasConceptScore W1915221427C40767141 @default.
• W1915221427 hasConceptScore W1915221427C54355233 @default.
• W1915221427 hasConceptScore W1915221427C83455156 @default.
• W1915221427 hasConceptScore W1915221427C86803240 @default.
• W1915221427 hasConceptScore W1915221427C97380033 @default.
• W1915221427 hasIssue "4" @default.
• W1915221427 hasLocation W19152214271 @default.

• next