Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915244501> ?p ?o ?g. }
- W1915244501 endingPage "336" @default.
- W1915244501 startingPage "315" @default.
- W1915244501 abstract "Nitric oxide (NO) is generated endogenously by NO synthases to regulate a number of physiological processes including cardiovascular and metabolic functions. A decrease in the production and bioavailability of NO is a hallmark of many major chronic diseases including hypertension, ischaemia-reperfusion injury, atherosclerosis and diabetes. This NO deficiency is mainly caused by dysfunctional NO synthases and increased scavenging of NO by the formation of reactive oxygen species. Inorganic nitrate and nitrite are emerging as substrates for in vivo NO synthase-independent formation of NO bioactivity. These anions are oxidation products of endogenous NO generation and are also present in the diet, with green leafy vegetables having a high nitrate content. The effects of nitrate and nitrite are diverse and include vasodilatation, improved endothelial function, enhanced mitochondrial efficiency and reduced generation of reactive oxygen species. Administration of nitrate or nitrite in animal models of cardiovascular disease shows promising results, and clinical trials are currently ongoing to investigate the therapeutic potential of nitrate and nitrite in hypertension, pulmonary hypertension, peripheral artery disease and myocardial infarction. In addition, the nutritional aspects of the nitrate-nitrite-NO pathway are interesting as diets suggested to protect against cardiovascular disease, such as the Mediterranean diet, are especially high in nitrate. Here, we discuss the potential therapeutic opportunities for nitrate and nitrite in prevention and treatment of cardiovascular and metabolic diseases." @default.
- W1915244501 created "2016-06-24" @default.
- W1915244501 creator A5014973031 @default.
- W1915244501 creator A5044817320 @default.
- W1915244501 creator A5061244573 @default.
- W1915244501 creator A5079244052 @default.
- W1915244501 date "2015-11-02" @default.
- W1915244501 modified "2023-10-18" @default.
- W1915244501 title "Therapeutic effects of inorganic nitrate and nitrite in cardiovascular and metabolic diseases" @default.
- W1915244501 cites W1507841416 @default.
- W1915244501 cites W1511302815 @default.
- W1915244501 cites W1524842621 @default.
- W1915244501 cites W1528220495 @default.
- W1915244501 cites W1537398036 @default.
- W1915244501 cites W1559904992 @default.
- W1915244501 cites W1616466978 @default.
- W1915244501 cites W1630609495 @default.
- W1915244501 cites W1956020477 @default.
- W1915244501 cites W1964555955 @default.
- W1915244501 cites W1965950958 @default.
- W1915244501 cites W1968286569 @default.
- W1915244501 cites W1969103666 @default.
- W1915244501 cites W1971447092 @default.
- W1915244501 cites W1973480138 @default.
- W1915244501 cites W1974358158 @default.
- W1915244501 cites W1974538071 @default.
- W1915244501 cites W1974558588 @default.
- W1915244501 cites W1974569195 @default.
- W1915244501 cites W1975578311 @default.
- W1915244501 cites W1978290051 @default.
- W1915244501 cites W1980023169 @default.
- W1915244501 cites W1980292532 @default.
- W1915244501 cites W1980450764 @default.
- W1915244501 cites W1980815873 @default.
- W1915244501 cites W1983339208 @default.
- W1915244501 cites W1983361198 @default.
- W1915244501 cites W1985227130 @default.
- W1915244501 cites W1985655562 @default.
- W1915244501 cites W1986470223 @default.
- W1915244501 cites W1986679171 @default.
- W1915244501 cites W1990527302 @default.
- W1915244501 cites W1994270731 @default.
- W1915244501 cites W1995330034 @default.
- W1915244501 cites W1995749170 @default.
- W1915244501 cites W1997023449 @default.
- W1915244501 cites W1997081772 @default.
- W1915244501 cites W1997395089 @default.
- W1915244501 cites W1998394852 @default.
- W1915244501 cites W1999575173 @default.
- W1915244501 cites W2000501615 @default.
- W1915244501 cites W2002956145 @default.
- W1915244501 cites W2003264248 @default.
- W1915244501 cites W2004691285 @default.
- W1915244501 cites W2005466083 @default.
- W1915244501 cites W2006705030 @default.
- W1915244501 cites W2007603349 @default.
- W1915244501 cites W2011904953 @default.
- W1915244501 cites W2014848058 @default.
- W1915244501 cites W2014944064 @default.
- W1915244501 cites W2015072722 @default.
- W1915244501 cites W2016139728 @default.
- W1915244501 cites W2016185716 @default.
- W1915244501 cites W2016213254 @default.
- W1915244501 cites W2017907872 @default.
- W1915244501 cites W2023421218 @default.
- W1915244501 cites W2025165424 @default.
- W1915244501 cites W2026713650 @default.
- W1915244501 cites W2028916136 @default.
- W1915244501 cites W2029124536 @default.
- W1915244501 cites W2033357754 @default.
- W1915244501 cites W2033384757 @default.
- W1915244501 cites W2036352285 @default.
- W1915244501 cites W2038965219 @default.
- W1915244501 cites W2041900921 @default.
- W1915244501 cites W2043562592 @default.
- W1915244501 cites W2043897455 @default.
- W1915244501 cites W2046663117 @default.
- W1915244501 cites W2047545717 @default.
- W1915244501 cites W2048216120 @default.
- W1915244501 cites W2048391225 @default.
- W1915244501 cites W2048635427 @default.
- W1915244501 cites W2049022142 @default.
- W1915244501 cites W2049131838 @default.
- W1915244501 cites W2049215298 @default.
- W1915244501 cites W2051071984 @default.
- W1915244501 cites W2051209160 @default.
- W1915244501 cites W2055095713 @default.
- W1915244501 cites W2056586704 @default.
- W1915244501 cites W2058137293 @default.
- W1915244501 cites W2062912375 @default.
- W1915244501 cites W2063680573 @default.
- W1915244501 cites W2065063113 @default.
- W1915244501 cites W2066082726 @default.
- W1915244501 cites W2066546505 @default.
- W1915244501 cites W2071755029 @default.
- W1915244501 cites W2073646379 @default.
- W1915244501 cites W2074035327 @default.
- W1915244501 cites W2074172668 @default.