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• W1915501887 endingPage "73" @default.
• W1915501887 startingPage "63" @default.
• W1915501887 abstract "Abstract Telomerase adds telomeric DNA repeats to telomeric termini using a sequence within its RNA subunit as a template. We characterized two mutations in the Kluyveromyces lactis telomerase RNA gene (TER1) template. Each initially produced normally regulated telomeres. One mutation, ter1-AA, had a cryptic defect in length regulation that was apparent only if the mutant gene was transformed into a TER1 deletion strain to permit extensive replacement of basal wild-type repeats with mutant repeats. This mutant differs from previously studied delayed elongation mutants in a number of properties. The second mutation, TER1-Bcl, which generates a BclI restriction site in newly synthesized telomeric repeats, was indistinguishable from wild type in all phenotypes assayed: cell growth, telomere length, and in vivo telomerase fidelity. TER1-Bcl cells demonstrated that the outer halves of the telomeric repeat tracts turn over within a few hundred cell divisions, while the innermost few repeats typically resisted turnover for at least 3000 cell divisions. Similarly deep but incomplete turnover was also observed in two other TER1 template mutants with highly elongated telomeres. These results indicate that most DNA turnover in functionally normal telomeres is due to gradual replicative sequence loss and additions by telomerase but that there are other processes that also contribute to turnover." @default.
• W1915501887 created "2016-06-24" @default.
• W1915501887 creator A5064437582 @default.
• W1915501887 creator A5077165250 @default.
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• W1915501887 date "2002-01-01" @default.
• W1915501887 modified "2023-10-15" @default.
• W1915501887 title "Dynamics of Telomeric DNA Turnover in Yeast" @default.
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• W1915501887 doi "https://doi.org/10.1093/genetics/160.1.63" @default.
• W1915501887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1461958" @default.
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• W1915501887 hasPublicationYear "2002" @default.
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