FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915672021> ?p ?o ?g. }

• W1915672021 endingPage "257" @default.
• W1915672021 startingPage "248" @default.
• W1915672021 abstract "Abstract The aim of this study was to evaluate and compare the effects of imatinib and nilotinib to that of silymarin on established liver fibrosis and oxidative stress in a thioacetamide (TAA) rat model. Male Wistar rats received intraperitoneal (i.p.) injections of TAA (150 mg/kg, twice weekly) for 12 weeks. Daily treatments with imatinib (10 mg/kg), nilotinib (10 mg/kg), and silymarin (100 mg/kg) were administered orally during the last 4 weeks of TAA‐administration. At the end of the study, hepatic damage was evaluated by analysis of liver function tests in serum. Hepatic histopathology and collagen content were employed to quantify liver fibrosis. Hepatic oxidative stress was assessed by measuring malondialdehyde (MDA), 4‐hydroxynonenal (4‐HNE), total nitrate/nitrite (NOx), and reduced glutathione (GSH) contents, as well as myeloperoxidase (MPO) and superoxide dismutase (SOD) activities. Nilotinib, silymarin and, to a lesser extent, imatinib treatments ameliorated TAA‐induced hepatic oxidative stress and damage as indicated by hepatic MDA, 4‐HNE, NOx, GSH, MPO and SOD levels, as well as liver function tests. Hepatic histopathology results revealed that nilotinib, imatinib, and silymarin treatments decreased the mean score of fibrosis in TAA‐treated rats by 24, 14, and 3%, respectively. However, nilotinib and silymarin, but not imatinib, treatments decreased hepatic collagen content in TAA‐treated rats by 17 and 36%, respectively. In conclusion, we demonstrated for the first time that nilotinib not only protected against hepatic oxidative stress, but also slowed down liver fibrosis progression. Thus, we provide the first evidence that nilotinib might be a promising anti‐fibrotic drug." @default.
• W1915672021 created "2016-06-24" @default.
• W1915672021 creator A5014496047 @default.
• W1915672021 creator A5021200402 @default.
• W1915672021 creator A5033197027 @default.
• W1915672021 creator A5062545400 @default.
• W1915672021 date "2011-03-09" @default.
• W1915672021 modified "2023-10-17" @default.
• W1915672021 title "Nilotinib counteracts thioacetamide-induced hepatic oxidative stress and attenuates liver fibrosis progression" @default.
• W1915672021 cites W181214577 @default.
• W1915672021 cites W1965026439 @default.
• W1915672021 cites W1968515912 @default.
• W1915672021 cites W1976176831 @default.
• W1915672021 cites W1981900811 @default.
• W1915672021 cites W1993124906 @default.
• W1915672021 cites W1993518161 @default.
• W1915672021 cites W1997405268 @default.
• W1915672021 cites W1997842448 @default.
• W1915672021 cites W1998990808 @default.
• W1915672021 cites W2007716611 @default.
• W1915672021 cites W2011852093 @default.
• W1915672021 cites W2016086822 @default.
• W1915672021 cites W2020188836 @default.
• W1915672021 cites W2025549575 @default.
• W1915672021 cites W2027113170 @default.
• W1915672021 cites W2045262851 @default.
• W1915672021 cites W2048192762 @default.
• W1915672021 cites W2048612060 @default.
• W1915672021 cites W2049602522 @default.
• W1915672021 cites W2054251966 @default.
• W1915672021 cites W2055615470 @default.
• W1915672021 cites W2056394193 @default.
• W1915672021 cites W2064473116 @default.
• W1915672021 cites W2065260824 @default.
• W1915672021 cites W2065824383 @default.
• W1915672021 cites W2069132215 @default.
• W1915672021 cites W2088866343 @default.
• W1915672021 cites W2093497322 @default.
• W1915672021 cites W2108518428 @default.
• W1915672021 cites W2115093096 @default.
• W1915672021 cites W2122386753 @default.
• W1915672021 cites W2124196948 @default.
• W1915672021 cites W2137488519 @default.
• W1915672021 cites W2138778824 @default.
• W1915672021 cites W2144304124 @default.
• W1915672021 cites W2152614687 @default.
• W1915672021 cites W4255712601 @default.
• W1915672021 cites W4255779404 @default.
• W1915672021 doi "https://doi.org/10.1111/j.1472-8206.2010.00824.x" @default.
• W1915672021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20408881" @default.
• W1915672021 hasPublicationYear "2011" @default.
• W1915672021 type Work @default.
• W1915672021 sameAs 1915672021 @default.
• W1915672021 citedByCount "49" @default.
• W1915672021 countsByYear W19156720212012 @default.
• W1915672021 countsByYear W19156720212013 @default.
• W1915672021 countsByYear W19156720212014 @default.
• W1915672021 countsByYear W19156720212015 @default.
• W1915672021 countsByYear W19156720212016 @default.
• W1915672021 countsByYear W19156720212017 @default.
• W1915672021 countsByYear W19156720212018 @default.
• W1915672021 countsByYear W19156720212019 @default.
• W1915672021 countsByYear W19156720212020 @default.
• W1915672021 countsByYear W19156720212021 @default.
• W1915672021 countsByYear W19156720212022 @default.
• W1915672021 countsByYear W19156720212023 @default.
• W1915672021 crossrefType "journal-article" @default.
• W1915672021 hasAuthorship W1915672021A5014496047 @default.
• W1915672021 hasAuthorship W1915672021A5021200402 @default.
• W1915672021 hasAuthorship W1915672021A5033197027 @default.
• W1915672021 hasAuthorship W1915672021A5062545400 @default.
• W1915672021 hasConcept C126322002 @default.
• W1915672021 hasConcept C134018914 @default.
• W1915672021 hasConcept C181199279 @default.
• W1915672021 hasConcept C185592680 @default.
• W1915672021 hasConcept C2775838275 @default.
• W1915672021 hasConcept C2776151105 @default.
• W1915672021 hasConcept C2777413986 @default.
• W1915672021 hasConcept C2777583451 @default.
• W1915672021 hasConcept C2778401633 @default.
• W1915672021 hasConcept C2778729363 @default.
• W1915672021 hasConcept C2780559512 @default.
• W1915672021 hasConcept C2781057625 @default.
• W1915672021 hasConcept C2993667909 @default.
• W1915672021 hasConcept C3019892230 @default.
• W1915672021 hasConcept C538909803 @default.
• W1915672021 hasConcept C55493867 @default.
• W1915672021 hasConcept C71924100 @default.
• W1915672021 hasConcept C98274493 @default.
• W1915672021 hasConceptScore W1915672021C126322002 @default.
• W1915672021 hasConceptScore W1915672021C134018914 @default.
• W1915672021 hasConceptScore W1915672021C181199279 @default.
• W1915672021 hasConceptScore W1915672021C185592680 @default.
• W1915672021 hasConceptScore W1915672021C2775838275 @default.
• W1915672021 hasConceptScore W1915672021C2776151105 @default.
• W1915672021 hasConceptScore W1915672021C2777413986 @default.
• W1915672021 hasConceptScore W1915672021C2777583451 @default.
• W1915672021 hasConceptScore W1915672021C2778401633 @default.

• next