Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915676936> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W1915676936 endingPage "3385" @default.
- W1915676936 startingPage "3378" @default.
- W1915676936 abstract "Abstract We previously found that lymph node T cells from 4-day-old, naive neonatal mice show diminished Th1-like responses. Neonatal T cells produced low levels of IL-2 and proliferated poorly in response to soluble anti-CD3 stimulation. However, neonatal T cells resembled Th2 cells (or primed adult T cells) in that they produced large amounts of IL-4. Here, we have investigated the importance of accessory cell signals in the diminished Th1-like responses of neonatal T cells. Anti-CD28 mAb greatly augmented IL-2 production by neonatal T cells in response to plate-bound anti-CD3 Ab. In response to soluble anti-CD3 mAb plus accessory cells, exogenous accessory cell-derived cytokines were sufficient to restore neonatal responses to adult-like levels. In the presence of exogenous IL-6, IL-4 production by neonatal T cells was largely unchanged whereas IL-2 production was dramatically increased, reaching the high levels produced by adult T cells. In addition, the presence of exogenous IL-6 enhanced the proliferation of neonatal T cells to adult levels. IL-6 also had marked effects on the capacity of neonatal T cells to respond to secondary stimuli. In the absence of exogenous IL-6, neonatal T cells responded poorly to secondary stimulation. This lack of responsiveness was not overcome by the addition of IL-2 or by stimulation with phorbol ester and calcium ionophore. When IL-6 was present during the primary stimulation, neonatal T cells, like adult T cells, produced high levels of IL-4 and proliferated extensively in response to secondary stimuli. Thus, IL-6 was sufficient to restore both the primary and secondary responses of neonatal T cells to mature, adult-like levels. These results imply that neonatal T cells have a greater requirement for accessory cell signals than do adult T cells and may have important bearing in overcoming neonatal T cell immunodeficiencies in vivo." @default.
- W1915676936 created "2016-06-24" @default.
- W1915676936 creator A5029309086 @default.
- W1915676936 creator A5044654489 @default.
- W1915676936 creator A5090653017 @default.
- W1915676936 date "1994-10-15" @default.
- W1915676936 modified "2023-10-10" @default.
- W1915676936 title "Up-regulation of murine neonatal T helper cell responses by accessory cell factors." @default.
- W1915676936 doi "https://doi.org/10.4049/jimmunol.153.8.3378" @default.
- W1915676936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7930563" @default.
- W1915676936 hasPublicationYear "1994" @default.
- W1915676936 type Work @default.
- W1915676936 sameAs 1915676936 @default.
- W1915676936 citedByCount "36" @default.
- W1915676936 countsByYear W19156769362021 @default.
- W1915676936 crossrefType "journal-article" @default.
- W1915676936 hasAuthorship W1915676936A5029309086 @default.
- W1915676936 hasAuthorship W1915676936A5044654489 @default.
- W1915676936 hasAuthorship W1915676936A5090653017 @default.
- W1915676936 hasBestOaLocation W19156769361 @default.
- W1915676936 hasConcept C126322002 @default.
- W1915676936 hasConcept C129374314 @default.
- W1915676936 hasConcept C134018914 @default.
- W1915676936 hasConcept C148125776 @default.
- W1915676936 hasConcept C203014093 @default.
- W1915676936 hasConcept C24998067 @default.
- W1915676936 hasConcept C2776090121 @default.
- W1915676936 hasConcept C71924100 @default.
- W1915676936 hasConcept C86803240 @default.
- W1915676936 hasConcept C8891405 @default.
- W1915676936 hasConceptScore W1915676936C126322002 @default.
- W1915676936 hasConceptScore W1915676936C129374314 @default.
- W1915676936 hasConceptScore W1915676936C134018914 @default.
- W1915676936 hasConceptScore W1915676936C148125776 @default.
- W1915676936 hasConceptScore W1915676936C203014093 @default.
- W1915676936 hasConceptScore W1915676936C24998067 @default.
- W1915676936 hasConceptScore W1915676936C2776090121 @default.
- W1915676936 hasConceptScore W1915676936C71924100 @default.
- W1915676936 hasConceptScore W1915676936C86803240 @default.
- W1915676936 hasConceptScore W1915676936C8891405 @default.
- W1915676936 hasIssue "8" @default.
- W1915676936 hasLocation W19156769361 @default.
- W1915676936 hasLocation W19156769362 @default.
- W1915676936 hasOpenAccess W1915676936 @default.
- W1915676936 hasPrimaryLocation W19156769361 @default.
- W1915676936 hasRelatedWork W1979841260 @default.
- W1915676936 hasRelatedWork W1984619393 @default.
- W1915676936 hasRelatedWork W2034768996 @default.
- W1915676936 hasRelatedWork W2042786471 @default.
- W1915676936 hasRelatedWork W2054992011 @default.
- W1915676936 hasRelatedWork W2060618991 @default.
- W1915676936 hasRelatedWork W2064416809 @default.
- W1915676936 hasRelatedWork W2163700154 @default.
- W1915676936 hasRelatedWork W2214620900 @default.
- W1915676936 hasRelatedWork W4312100064 @default.
- W1915676936 hasVolume "153" @default.
- W1915676936 isParatext "false" @default.
- W1915676936 isRetracted "false" @default.
- W1915676936 magId "1915676936" @default.
- W1915676936 workType "article" @default.