FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915697590> ?p ?o ?g. }

• W1915697590 endingPage "631" @default.
• W1915697590 startingPage "620" @default.
• W1915697590 abstract "Osteonecrosis of the femoral head is a serious orthopedic problem. Moderate loads with knee loading promote bone formation, but their effects on osteonecrosis have not been investigated. Using a rat model, we examined a hypothesis that knee loading enhances vessel remodeling and bone healing through the modulation of the fate of bone marrow-derived cells. In this study, osteonecrosis was induced by transecting the ligamentum teres followed by a tight ligature around the femoral neck. For knee loading, 5 N loads were laterally applied to the knee at 15 Hz for 5 min/day for 5 weeks. Changes in bone mineral density (BMD) and bone mineral content (BMC) of the femur were measured by pDEXA, and ink infusion was performed to evaluate vessel remodeling. Femoral heads were harvested for histomorphometry, and bone marrow-derived cells were isolated to examine osteoclast development and osteoblast differentiation. The results showed that osteonecrosis significantly induced bone loss, and knee loading stimulated both vessel remodeling and bone healing. The osteonecrosis group exhibited the lowest trabecular BV/TV (p < 0.001) in the femoral head, and lowest femoral BMD and BMC (both p < 0.01). However, knee loading increased trabecular BV/TV (p < 0.05) as well as BMD (p < 0.05) and BMC (p < 0.01). Osteonecrosis decreased the vessel volume (p < 0.001), vessel number (p < 0.001) and VEGF expression (p < 0.01), and knee loading increased them (p < 0.001, p < 0.001 and p < 0.01). Osteonecrosis activated osteoclast development, and knee loading reduced its formation, migration, adhesion and the level of “pit” formation (p < 0.001, p < 0.01, p < 0.001 and p < 0.001). Furthermore, knee loading significantly increased osteoblast differentiation and CFU-F (both p < 0.001). A significantly positive correlation was observed between vessel remodeling and bone healing (both p < 0.01). These results indicate that knee loading could be effective in repair osteonecrosis of the femoral head in a rat model. This effect might be attributed to promoting vessel remodeling, suppressing osteoclast development, and increasing osteoblast and fibroblast differentiation. In summary, the current study suggests that knee loading might potentially be employed as a non-invasive therapy for osteonecrosis of the femoral head." @default.
• W1915697590 created "2016-06-24" @default.
• W1915697590 creator A5006636063 @default.
• W1915697590 creator A5038218094 @default.
• W1915697590 creator A5055151897 @default.
• W1915697590 creator A5062607928 @default.
• W1915697590 creator A5081940051 @default.
• W1915697590 creator A5088731186 @default.
• W1915697590 date "2015-12-01" @default.
• W1915697590 modified "2023-09-29" @default.
• W1915697590 title "Knee loading protects against osteonecrosis of the femoral head by enhancing vessel remodeling and bone healing" @default.
• W1915697590 cites W101747906 @default.
• W1915697590 cites W1546919480 @default.
• W1915697590 cites W183152190 @default.
• W1915697590 cites W1914349896 @default.
• W1915697590 cites W1926920256 @default.
• W1915697590 cites W1964076164 @default.
• W1915697590 cites W1966307525 @default.
• W1915697590 cites W1983468721 @default.
• W1915697590 cites W1987138240 @default.
• W1915697590 cites W1989944094 @default.
• W1915697590 cites W2011929523 @default.
• W1915697590 cites W2013791944 @default.
• W1915697590 cites W2021173283 @default.
• W1915697590 cites W2025869292 @default.
• W1915697590 cites W2031793283 @default.
• W1915697590 cites W2033628492 @default.
• W1915697590 cites W2034124091 @default.
• W1915697590 cites W2037009818 @default.
• W1915697590 cites W2043825322 @default.
• W1915697590 cites W2047588969 @default.
• W1915697590 cites W2055090398 @default.
• W1915697590 cites W2056083363 @default.
• W1915697590 cites W2056851407 @default.
• W1915697590 cites W2060862711 @default.
• W1915697590 cites W2061261019 @default.
• W1915697590 cites W2069160495 @default.
• W1915697590 cites W2070736285 @default.
• W1915697590 cites W2079302844 @default.
• W1915697590 cites W2083178141 @default.
• W1915697590 cites W2089590765 @default.
• W1915697590 cites W2094235710 @default.
• W1915697590 cites W2104772053 @default.
• W1915697590 cites W2104995688 @default.
• W1915697590 cites W2115800951 @default.
• W1915697590 cites W2117596907 @default.
• W1915697590 cites W2119096385 @default.
• W1915697590 cites W2121626245 @default.
• W1915697590 cites W2126496450 @default.
• W1915697590 cites W2127367994 @default.
• W1915697590 cites W2130281059 @default.
• W1915697590 cites W2137698658 @default.
• W1915697590 cites W2141612242 @default.
• W1915697590 cites W2157440251 @default.
• W1915697590 cites W2158225662 @default.
• W1915697590 cites W2162980529 @default.
• W1915697590 cites W2170625083 @default.
• W1915697590 cites W2171845781 @default.
• W1915697590 cites W2336007082 @default.
• W1915697590 doi "https://doi.org/10.1016/j.bone.2015.09.012" @default.
• W1915697590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4641018" @default.
• W1915697590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26416150" @default.
• W1915697590 hasPublicationYear "2015" @default.
• W1915697590 type Work @default.
• W1915697590 sameAs 1915697590 @default.
• W1915697590 citedByCount "27" @default.
• W1915697590 countsByYear W19156975902016 @default.
• W1915697590 countsByYear W19156975902017 @default.
• W1915697590 countsByYear W19156975902018 @default.
• W1915697590 countsByYear W19156975902019 @default.
• W1915697590 countsByYear W19156975902020 @default.
• W1915697590 countsByYear W19156975902021 @default.
• W1915697590 countsByYear W19156975902022 @default.
• W1915697590 countsByYear W19156975902023 @default.
• W1915697590 crossrefType "journal-article" @default.
• W1915697590 hasAuthorship W1915697590A5006636063 @default.
• W1915697590 hasAuthorship W1915697590A5038218094 @default.
• W1915697590 hasAuthorship W1915697590A5055151897 @default.
• W1915697590 hasAuthorship W1915697590A5062607928 @default.
• W1915697590 hasAuthorship W1915697590A5081940051 @default.
• W1915697590 hasAuthorship W1915697590A5088731186 @default.
• W1915697590 hasBestOaLocation W19156975902 @default.
• W1915697590 hasConcept C105702510 @default.
• W1915697590 hasConcept C126322002 @default.
• W1915697590 hasConcept C126894567 @default.
• W1915697590 hasConcept C141071460 @default.
• W1915697590 hasConcept C170033053 @default.
• W1915697590 hasConcept C170493617 @default.
• W1915697590 hasConcept C185592680 @default.
• W1915697590 hasConcept C202751555 @default.
• W1915697590 hasConcept C2775854910 @default.
• W1915697590 hasConcept C2776033226 @default.
• W1915697590 hasConcept C2776541429 @default.
• W1915697590 hasConcept C2776886416 @default.
• W1915697590 hasConcept C2778260815 @default.
• W1915697590 hasConcept C2779100257 @default.
• W1915697590 hasConcept C2780007613 @default.
• W1915697590 hasConcept C2780554211 @default.

• next