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- W1915852068 abstract "Introduction The contributions of the T-cell population and Natural Killer cells have been extensively studied in relation to pregnancy and adverse pregnancy outcomes. Less attention has been given to the B-cell population although maternal levels of circulating autoantibodies against the angiotensin II type 1 (AT1)-receptor and antiphospholipid antibodies (aPLs) have been shown to be associated with preeclampsia. Members of the PAR (protease activated receptor) family and VEGF (vascular endothelial growth factor) family have previously been shown to be implicated in preeclampsia. Objectives The aim of this exploratory study was to study levels of IgG autoantibodies against these families of PAR and VEGF proteins in pregnant women with and without preeclampsia. Methods We developed novel immunoassays detecting levels of IgG autoantibodies against PAR-1, PAR-2, PlGF (Placental Growth Factor), VEGF-A, VEGF-B, VEGF-receptor 1 (VEGFR-1) and VEGF receptor 2 (VEGFR-2). Results We found that levels of autoantibodies against PAR-1, PAR-2, VEGF-A, VEGF-B, PlGF, VEGFR-1 and VEGFR-2 were lower ( p n =42) compared to normotensive pregnancies ( n =46). Clinical features associated with augmented risk for the preeclampsia syndrome (such as primigravidity, primiparity, obesity and a small for gestational age fetus) were also associated with lower levels of the autoantibodies we investigated, although not always reaching statistical significance. Conclusion We speculate that these autoantibodies may play a protective role in the development of preeclampsia and are involved in the dysregulation of the PAR and VEGF pathways." @default.
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- W1915852068 date "2015-07-01" @default.
- W1915852068 modified "2023-10-02" @default.
- W1915852068 title "P46. Dysregulated level of novel circulating autoantibodies in preeclampsia" @default.
- W1915852068 doi "https://doi.org/10.1016/j.preghy.2015.07.099" @default.
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