FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915967794> ?p ?o ?g. }

• W1915967794 abstract "Selective capture of disease-related proteins in complex biological fluids and tissues is an important aim in developing sensitive protein biosensors for in vivo applications. Microprojection arrays are biomedical devices whose mechanical and chemical properties can be tuned to allow efficient penetration of skin, coupled with highly selective biomarker capture from the complex biological environment of skin tissue. Herein, the authors describe an improved surface modification strategy to produce amine-modified polycarbonate arrays, followed by the attachment of an antifouling poly(sulfobetaine-methacrylate) (pSBMA) polymer or a linear polyethylene glycol (PEG) polymer of comparative molecular weight and hydrodynamic radius. Using a grafting to approach, pSBMA and linear PEG coatings yielded comparative antifouling behavior in single protein solutions, diluted plasma, or when applied to mouse flank skin penetrating into the vascularized dermal tissue. Interestingly, the density of immobilized immunoglobulin G (IgG) or bovine serum albumin protein on pSBMA surfaces was significantly higher than that on the PEG surfaces, while the nonspecific adsorption was comparable for each protein. When incubated in buffer or plasma solutions containing dengue non-structural protein 1 (NS1), anti-NS1-IgG-coated pSBMA surfaces captured significantly more NS1 in comparison to PEG-coated devices. Similarly, when wearable microprojection arrays were applied to the skin of dengue-infected mice using the same coatings, the pSBMA-coated devices showed significantly higher capture efficiency (>2-fold increase in signal) than the PEG-coated substrates, which showed comparative signal when applied to naïve mice. In conclusion, zwitterionic pSBMA polymers (of equivalent hydrodynamic radii to PEG) allowed detection of dengue NS1 disease biomarker in a preclinical model of dengue infection, showing significantly higher signal-to-noise ratio in comparison to the PEG controls. The results of this study will be useful in the future development of a range of protein biosensors designed for use in vivo." @default.
• W1915967794 created "2016-06-24" @default.
• W1915967794 creator A5014665196 @default.
• W1915967794 creator A5023218926 @default.
• W1915967794 creator A5023320794 @default.
• W1915967794 creator A5032624215 @default.
• W1915967794 creator A5035480938 @default.
• W1915967794 creator A5038629041 @default.
• W1915967794 creator A5072766818 @default.
• W1915967794 creator A5082337082 @default.
• W1915967794 date "2015-10-07" @default.
• W1915967794 modified "2023-09-25" @default.
• W1915967794 title "Comparison between polyethylene glycol and zwitterionic polymers as antifouling coatings on wearable devices for selective antigen capture from biological tissue" @default.
• W1915967794 cites W1977054660 @default.
• W1915967794 cites W2003570790 @default.
• W1915967794 cites W2005132685 @default.
• W1915967794 cites W2005263127 @default.
• W1915967794 cites W2006008435 @default.
• W1915967794 cites W2006240270 @default.
• W1915967794 cites W2008589078 @default.
• W1915967794 cites W2009278211 @default.
• W1915967794 cites W2010305352 @default.
• W1915967794 cites W2014579253 @default.
• W1915967794 cites W2020558577 @default.
• W1915967794 cites W2021060402 @default.
• W1915967794 cites W2024104289 @default.
• W1915967794 cites W2026077248 @default.
• W1915967794 cites W2030835540 @default.
• W1915967794 cites W2033809039 @default.
• W1915967794 cites W2039779814 @default.
• W1915967794 cites W2042823010 @default.
• W1915967794 cites W2043704558 @default.
• W1915967794 cites W2044173019 @default.
• W1915967794 cites W2044187349 @default.
• W1915967794 cites W2045172810 @default.
• W1915967794 cites W2048808551 @default.
• W1915967794 cites W2059702407 @default.
• W1915967794 cites W2061759175 @default.
• W1915967794 cites W2071662504 @default.
• W1915967794 cites W2073335158 @default.
• W1915967794 cites W2074469051 @default.
• W1915967794 cites W2076911232 @default.
• W1915967794 cites W2082700989 @default.
• W1915967794 cites W2082877002 @default.
• W1915967794 cites W2090214386 @default.
• W1915967794 cites W2091445204 @default.
• W1915967794 cites W2107660675 @default.
• W1915967794 cites W2118618680 @default.
• W1915967794 cites W2131082021 @default.
• W1915967794 cites W2134282868 @default.
• W1915967794 cites W2148235776 @default.
• W1915967794 cites W2148296626 @default.
• W1915967794 cites W2149292906 @default.
• W1915967794 cites W2152921610 @default.
• W1915967794 cites W2160471784 @default.
• W1915967794 cites W2165268405 @default.
• W1915967794 cites W2166505723 @default.
• W1915967794 cites W2172116519 @default.
• W1915967794 cites W2503895349 @default.
• W1915967794 doi "https://doi.org/10.1116/1.4932055" @default.
• W1915967794 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26446192" @default.
• W1915967794 hasPublicationYear "2015" @default.
• W1915967794 type Work @default.
• W1915967794 sameAs 1915967794 @default.
• W1915967794 citedByCount "21" @default.
• W1915967794 countsByYear W19159677942015 @default.
• W1915967794 countsByYear W19159677942016 @default.
• W1915967794 countsByYear W19159677942017 @default.
• W1915967794 countsByYear W19159677942018 @default.
• W1915967794 countsByYear W19159677942019 @default.
• W1915967794 countsByYear W19159677942020 @default.
• W1915967794 countsByYear W19159677942021 @default.
• W1915967794 countsByYear W19159677942022 @default.
• W1915967794 crossrefType "journal-article" @default.
• W1915967794 hasAuthorship W1915967794A5014665196 @default.
• W1915967794 hasAuthorship W1915967794A5023218926 @default.
• W1915967794 hasAuthorship W1915967794A5023320794 @default.
• W1915967794 hasAuthorship W1915967794A5032624215 @default.
• W1915967794 hasAuthorship W1915967794A5035480938 @default.
• W1915967794 hasAuthorship W1915967794A5038629041 @default.
• W1915967794 hasAuthorship W1915967794A5072766818 @default.
• W1915967794 hasAuthorship W1915967794A5082337082 @default.
• W1915967794 hasConcept C10138342 @default.
• W1915967794 hasConcept C127413603 @default.
• W1915967794 hasConcept C132050475 @default.
• W1915967794 hasConcept C150394285 @default.
• W1915967794 hasConcept C15920480 @default.
• W1915967794 hasConcept C160756335 @default.
• W1915967794 hasConcept C162324750 @default.
• W1915967794 hasConcept C178790620 @default.
• W1915967794 hasConcept C185592680 @default.
• W1915967794 hasConcept C188027245 @default.
• W1915967794 hasConcept C2776964284 @default.
• W1915967794 hasConcept C41625074 @default.
• W1915967794 hasConcept C42360764 @default.
• W1915967794 hasConcept C521977710 @default.
• W1915967794 hasConcept C54400483 @default.
• W1915967794 hasConcept C55493867 @default.
• W1915967794 hasConcept C6047279 @default.
• W1915967794 hasConcept C88001094 @default.

• next