FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1915984003> ?p ?o ?g. }

• W1915984003 endingPage "3408" @default.
• W1915984003 startingPage "3401" @default.
• W1915984003 abstract "The present study investigated the fate of macrophages in peripheral nerves undergoing Wallerian degeneration, especially their disappearance from the injured nerves after phagocytosis of axonal and myelin debris. Wallerian degeneration was induced in adult male C57Bl/6 mice by transecting the right sciatic nerve. Five days after transection, the male sciatic nerves were transplanted into female recipient mice by placing them exactly parallel to the host sciatic nerves. Nerves of the female recipient mice were also transected to induce breakdown of the blood–nerve barrier in the host animal. Apoptosis was assessed by morphological, immunohistochemical (activated caspase-3), and molecular (DNA fragmentation) methods in transplanted, recipient, and in control nerves. A subpopulation of macrophages within the degenerating nerves died locally by apoptosis in each experiment. The fate of the male macrophages within the transplanted nerves and the host organism was investigated by in situ hybridization with a Y-chromosome-specific DNA probe (145SC5). In situ hybridization specifically stained cells within the transplanted male nerve. Y-chromosome-positive cells were detected not only inside the transplanted nerve, but also inside the female host nerve, the perineurial tissue, the local perineurial blood vessels, draining lymph nodes and the spleen of the female host, suggesting hematogenous as well as lymphatic elimination of macrophages from the injured nerve. These data indicate that local apoptosis and systemic elimination via circulation to the local lymph nodes and the spleen are involved in the disappearance of macrophages from the injured peripheral nervous system." @default.
• W1915984003 created "2016-06-24" @default.
• W1915984003 creator A5006000088 @default.
• W1915984003 creator A5011568313 @default.
• W1915984003 creator A5048801608 @default.
• W1915984003 creator A5049855592 @default.
• W1915984003 creator A5069059723 @default.
• W1915984003 date "2001-05-15" @default.
• W1915984003 modified "2023-10-02" @default.
• W1915984003 title "Macrophages Are Eliminated from the Injured Peripheral Nerve via Local Apoptosis and Circulation to Regional Lymph Nodes and the Spleen" @default.
• W1915984003 cites W1547417644 @default.
• W1915984003 cites W1780460389 @default.
• W1915984003 cites W1862126192 @default.
• W1915984003 cites W1911014954 @default.
• W1915984003 cites W1944757416 @default.
• W1915984003 cites W1964748039 @default.
• W1915984003 cites W1968876292 @default.
• W1915984003 cites W1975989693 @default.
• W1915984003 cites W1981089875 @default.
• W1915984003 cites W1991735848 @default.
• W1915984003 cites W2006463181 @default.
• W1915984003 cites W2008431619 @default.
• W1915984003 cites W2013497145 @default.
• W1915984003 cites W2015625647 @default.
• W1915984003 cites W2021338058 @default.
• W1915984003 cites W2025955916 @default.
• W1915984003 cites W2032317878 @default.
• W1915984003 cites W2033018630 @default.
• W1915984003 cites W2035330294 @default.
• W1915984003 cites W2037368493 @default.
• W1915984003 cites W2042438243 @default.
• W1915984003 cites W2042920781 @default.
• W1915984003 cites W2044674654 @default.
• W1915984003 cites W2045880711 @default.
• W1915984003 cites W2048907346 @default.
• W1915984003 cites W2061497413 @default.
• W1915984003 cites W2064353840 @default.
• W1915984003 cites W2067709496 @default.
• W1915984003 cites W2068639096 @default.
• W1915984003 cites W2070757813 @default.
• W1915984003 cites W2071496573 @default.
• W1915984003 cites W2072049083 @default.
• W1915984003 cites W2075324940 @default.
• W1915984003 cites W2076818528 @default.
• W1915984003 cites W2083132165 @default.
• W1915984003 cites W2085936751 @default.
• W1915984003 cites W2091455355 @default.
• W1915984003 cites W2105037115 @default.
• W1915984003 cites W2114817502 @default.
• W1915984003 cites W2118741542 @default.
• W1915984003 cites W2119543039 @default.
• W1915984003 cites W2122305954 @default.
• W1915984003 cites W2126024623 @default.
• W1915984003 cites W2137033662 @default.
• W1915984003 cites W2141501885 @default.
• W1915984003 cites W2159650080 @default.
• W1915984003 cites W2160272188 @default.
• W1915984003 cites W2162741656 @default.
• W1915984003 cites W2166037061 @default.
• W1915984003 cites W2409272776 @default.
• W1915984003 cites W2977568416 @default.
• W1915984003 cites W41143140 @default.
• W1915984003 cites W4211264883 @default.
• W1915984003 cites W4252463664 @default.
• W1915984003 cites W4253210742 @default.
• W1915984003 cites W4296792904 @default.
• W1915984003 cites W2106544382 @default.
• W1915984003 cites W2419587365 @default.
• W1915984003 doi "https://doi.org/10.1523/jneurosci.21-10-03401.2001" @default.
• W1915984003 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6762479" @default.
• W1915984003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11331370" @default.
• W1915984003 hasPublicationYear "2001" @default.
• W1915984003 type Work @default.
• W1915984003 sameAs 1915984003 @default.
• W1915984003 citedByCount "58" @default.
• W1915984003 countsByYear W19159840032012 @default.
• W1915984003 countsByYear W19159840032013 @default.
• W1915984003 countsByYear W19159840032014 @default.
• W1915984003 countsByYear W19159840032015 @default.
• W1915984003 countsByYear W19159840032016 @default.
• W1915984003 countsByYear W19159840032017 @default.
• W1915984003 countsByYear W19159840032018 @default.
• W1915984003 countsByYear W19159840032019 @default.
• W1915984003 countsByYear W19159840032020 @default.
• W1915984003 countsByYear W19159840032021 @default.
• W1915984003 countsByYear W19159840032022 @default.
• W1915984003 countsByYear W19159840032023 @default.
• W1915984003 crossrefType "journal-article" @default.
• W1915984003 hasAuthorship W1915984003A5006000088 @default.
• W1915984003 hasAuthorship W1915984003A5011568313 @default.
• W1915984003 hasAuthorship W1915984003A5048801608 @default.
• W1915984003 hasAuthorship W1915984003A5049855592 @default.
• W1915984003 hasAuthorship W1915984003A5069059723 @default.
• W1915984003 hasBestOaLocation W19159840031 @default.
• W1915984003 hasConcept C104317684 @default.
• W1915984003 hasConcept C105702510 @default.
• W1915984003 hasConcept C142724271 @default.
• W1915984003 hasConcept C150194340 @default.

• next