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- W1916084024 endingPage "2922" @default.
- W1916084024 startingPage "2911" @default.
- W1916084024 abstract "Colorectal cancer (CRC) is the third leading cancer worldwide and CRC-related death is mainly attributed to metastasis. Many cellular signaling pathways have been demonstrated to be aberrant in colorectal tumors, and some of them lead to the acquisition of malignant phenotypes. Therefore, the evaluation of signaling pathways implicated in CRC metastasis is urgent for further understanding of CRC progression and pharmacotherapy. This review focuses on several novel cellular signaling pathways associated with CRC metastasis, including Wnt/β-catenin, p53, COX, TGF-β/Smad, NF-κB, Notch, VEGF and JAKs/STAT3 signaling pathways. Targeted agents developed based on these pathways are also briefly discussed." @default.
- W1916084024 created "2016-06-24" @default.
- W1916084024 creator A5020746135 @default.
- W1916084024 creator A5054844187 @default.
- W1916084024 creator A5069028088 @default.
- W1916084024 creator A5070110008 @default.
- W1916084024 date "2015-11-01" @default.
- W1916084024 modified "2023-10-16" @default.
- W1916084024 title "Cellular signaling pathways implicated in metastasis of colorectal cancer and the associated targeted agents" @default.
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- W1916084024 doi "https://doi.org/10.2217/fon.15.235" @default.
- W1916084024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26414153" @default.
- W1916084024 hasPublicationYear "2015" @default.
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