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• W1916392388 endingPage "470" @default.
• W1916392388 startingPage "453" @default.
• W1916392388 abstract "Summary Lipid metabolism in T rypanosoma brucei , the causative agent of African sleeping sickness, differs from its human host in several fundamental ways. This has lead to the validation of a plethora of novel drug targets, giving hope of novel chemical intervention against this neglected disease. Cytidine diphosphate diacylglycerol ( CDP‐DAG ) is a central lipid intermediate for several pathways in both prokaryotes and eukaryotes, being produced by CDP‐DAG synthase ( CDS ). However, nothing is known about the single T . brucei CDS gene ( Tb 927.7.220/ EC 2.7.7.41) or its activity. In this study we show TbCDS is functional by complementation of a non‐viable yeast CDS null strain and that it is essential in the bloodstream form of the parasite via a conditional knockout. The TbCDS conditional knockout showed morphological changes including a cell‐cycle arrest due in part to kinetoplast segregation defects. Biochemical phenotyping of TbCDS conditional knockout showed drastically altered lipid metabolism where reducing levels of phosphatidylinositol detrimentally impacted on glycoylphosphatidylinositol biosynthesis. These studies also suggest that phosphatidylglycerol synthesized via the phosphatidylglycerol‐phosphate synthase is not synthesized from CDP‐DAG , as was previously thought. TbCDS was shown to localized the ER and G olgi, probably to provide CDP‐DAG for the phosphatidylinositol synthases." @default.
• W1916392388 created "2016-06-24" @default.
• W1916392388 creator A5001393183 @default.
• W1916392388 creator A5041007964 @default.
• W1916392388 creator A5055163686 @default.
• W1916392388 creator A5083819996 @default.
• W1916392388 creator A5086350788 @default.
• W1916392388 date "2014-03-28" @default.
• W1916392388 modified "2023-10-03" @default.
• W1916392388 title "The essential roles of cytidine diphosphate‐diacylglycerol synthase in bloodstream form<i><scp>T</scp>rypanosoma brucei</i>" @default.
• W1916392388 cites W1424883175 @default.
• W1916392388 cites W1486852747 @default.
• W1916392388 cites W1491104009 @default.
• W1916392388 cites W1522884769 @default.
• W1916392388 cites W1524373157 @default.
• W1916392388 cites W1541106822 @default.
• W1916392388 cites W1541497469 @default.
• W1916392388 cites W1543361103 @default.
• W1916392388 cites W1564289759 @default.
• W1916392388 cites W1568352573 @default.
• W1916392388 cites W1607921146 @default.
• W1916392388 cites W1612466044 @default.
• W1916392388 cites W1643887333 @default.
• W1916392388 cites W1911244345 @default.
• W1916392388 cites W1939117002 @default.
• W1916392388 cites W1969141587 @default.
• W1916392388 cites W1973222341 @default.
• W1916392388 cites W1975304761 @default.
• W1916392388 cites W1977172528 @default.
• W1916392388 cites W1987081804 @default.
• W1916392388 cites W1989743311 @default.
• W1916392388 cites W1990697320 @default.
• W1916392388 cites W1992707039 @default.
• W1916392388 cites W2003017010 @default.
• W1916392388 cites W2005678289 @default.
• W1916392388 cites W2006244481 @default.
• W1916392388 cites W2010689036 @default.
• W1916392388 cites W2030915307 @default.
• W1916392388 cites W2033238750 @default.
• W1916392388 cites W2036354940 @default.
• W1916392388 cites W2046046963 @default.
• W1916392388 cites W2049330179 @default.
• W1916392388 cites W2051758651 @default.
• W1916392388 cites W2052480751 @default.
• W1916392388 cites W2053396821 @default.
• W1916392388 cites W2058992886 @default.
• W1916392388 cites W2061758241 @default.
• W1916392388 cites W2062862560 @default.
• W1916392388 cites W2063287165 @default.
• W1916392388 cites W2064198724 @default.
• W1916392388 cites W2067125291 @default.
• W1916392388 cites W2067596083 @default.
• W1916392388 cites W2068068578 @default.
• W1916392388 cites W2075094746 @default.
• W1916392388 cites W2075392873 @default.
• W1916392388 cites W2086660631 @default.
• W1916392388 cites W2087407928 @default.
• W1916392388 cites W2087917314 @default.
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• W1916392388 cites W2098329073 @default.
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• W1916392388 cites W2111994085 @default.
• W1916392388 cites W2116350092 @default.
• W1916392388 cites W2118305715 @default.
• W1916392388 cites W2119919876 @default.
• W1916392388 cites W2120435968 @default.
• W1916392388 cites W2122775632 @default.
• W1916392388 cites W2123834396 @default.
• W1916392388 cites W2127322768 @default.
• W1916392388 cites W2127997630 @default.
• W1916392388 cites W2128110141 @default.
• W1916392388 cites W2130323754 @default.
• W1916392388 cites W2136386164 @default.
• W1916392388 cites W2140948740 @default.
• W1916392388 cites W2154261496 @default.
• W1916392388 cites W2157513547 @default.
• W1916392388 cites W2162724326 @default.
• W1916392388 cites W2163182603 @default.
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• W1916392388 cites W2168248533 @default.
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• W1916392388 doi "https://doi.org/10.1111/mmi.12553" @default.
• W1916392388 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114554" @default.
• W1916392388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24533860" @default.
• W1916392388 hasPublicationYear "2014" @default.
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