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• W1916405786 abstract "Serotoninergic dysfunction was reported to be involved in aetiology of temporal lobe epilepsy (TLE). Serotonin (5-HT) is actively cleared from synaptic cleft by serotonin transporter (5-HTT). We investigated the association between three common polymorphisms of 5-HTT gene, which may influence gene expression or function, and risk for TLE.Three hundred and thirty-four patients with TLE and four hundred and eighty-seven non-epileptic control subjects from Han Chinese origin were enrolled for the present study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping.10-repeat allele frequency of 17 bp variable number of tandem repeats in the second intron (5-HTTVNTR) was moderately higher in patients with TLE than in controls (9.1% vs. 6.1%, P=0.0187, OR=1.55, 95%CI=1.07-2.26).Our study suggested 10-repeat allele of 5-HTTVNTR may be associated with TLE susceptibility." @default.
• W1916405786 created "2016-06-24" @default.
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• W1916405786 date "2011-09-27" @default.
• W1916405786 modified "2023-10-14" @default.
• W1916405786 title "Association study of functional polymorphisms in serotonin transporter gene with temporal lobe epilepsy in Han Chinese population" @default.
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• W1916405786 doi "https://doi.org/10.1111/j.1468-1331.2011.03521.x" @default.
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