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- W191646008 abstract "Since the early 1990s, our understanding of how epithelial and stromal cells interact in 3D tissue-engineered constructs has led to tissue-engineered skin and oral mucosa models, which are beginning to deliver benefit in the clinic (usually in small-scale reconstructive surgery procedures) but have a great deal to offer for in vitro investigations. These 3D tissue-engineered models can be used for a wide variety of purposes such as dermato- and mucotoxicity, wound healing, examination of pigmentation and melanoma biology, and in particular, a recent development from this laboratory, as a model of bacterially infected skin. Models can also be used to investigate specific skin disease processes. In this chapter, we describe the basic methodology for producing 3D tissue-engineered skin and oral mucosa based on de-epidermised acellular human dermis, and we give examples of how these models can be used for a variety of applications." @default.
- W191646008 created "2016-06-24" @default.
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- W191646008 date "2010-10-07" @default.
- W191646008 modified "2023-10-18" @default.
- W191646008 title "Production of Tissue-Engineered Skin and Oral Mucosa for Clinical and Experimental Use" @default.
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- W191646008 doi "https://doi.org/10.1007/978-1-60761-984-0_9" @default.
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