Matches in SemOpenAlex for { <https://semopenalex.org/work/W1916493755> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1916493755 abstract "The role of platelets in infection and immunity is an exciting new theme, which is rapidly evolving. In this thesis we studied the involvement of platelets in the host response to pneumonia and sepsis. We made use of well established mouse models in which mice were infected with a bacterial inoculum via the airways, where after either clinical symptoms and mortality were scored, or experiments were terminated at predefined time points in order to obtain insight in bacterial growth, dissemination and in host responses. Platelets were investigated in this setting by (dose dependently) depleting the cell type or genetically altering diverse platelet signaling pathways or responses. We also aimed to better understand the role of platelet activation in a clinical setting and investigated the influence of pre-existing antiplatelet therapy on disease outcome in a prospectively followed sepsis cohort. Our main results were that low platelet counts render animals more susceptible to uncontrolled growth and dissemination of bacteria, resulting in enhanced mortality. On the other hand, platelets can contribute to organ damage caused by severe infection, exemplifying the double-edged-sword character of the action of these cells. Platelet-expressed P-selectin and Protease activated receptor 4 seemed indispensable for adequate host response, while platelet Toll-like receptor signaling was found to be of insignificant importance during severe infection. The time that platelets were merely viewed upon as cells important for primary hemostasis is way beyond us. In this thesis we make a strong argument that platelets play a multifaceted role in infection." @default.
- W1916493755 created "2016-06-24" @default.
- W1916493755 creator A5001280693 @default.
- W1916493755 date "2015-01-01" @default.
- W1916493755 modified "2023-09-25" @default.
- W1916493755 title "Platelets: versatile effector cells in pneumonia and sepsis" @default.
- W1916493755 hasPublicationYear "2015" @default.
- W1916493755 type Work @default.
- W1916493755 sameAs 1916493755 @default.
- W1916493755 citedByCount "0" @default.
- W1916493755 crossrefType "journal-article" @default.
- W1916493755 hasAuthorship W1916493755A5001280693 @default.
- W1916493755 hasConcept C126322002 @default.
- W1916493755 hasConcept C170493617 @default.
- W1916493755 hasConcept C203014093 @default.
- W1916493755 hasConcept C2777628635 @default.
- W1916493755 hasConcept C2777914695 @default.
- W1916493755 hasConcept C2778384902 @default.
- W1916493755 hasConcept C2778589496 @default.
- W1916493755 hasConcept C2779341262 @default.
- W1916493755 hasConcept C3018697912 @default.
- W1916493755 hasConcept C51785407 @default.
- W1916493755 hasConcept C71924100 @default.
- W1916493755 hasConcept C86803240 @default.
- W1916493755 hasConcept C8891405 @default.
- W1916493755 hasConcept C89560881 @default.
- W1916493755 hasConceptScore W1916493755C126322002 @default.
- W1916493755 hasConceptScore W1916493755C170493617 @default.
- W1916493755 hasConceptScore W1916493755C203014093 @default.
- W1916493755 hasConceptScore W1916493755C2777628635 @default.
- W1916493755 hasConceptScore W1916493755C2777914695 @default.
- W1916493755 hasConceptScore W1916493755C2778384902 @default.
- W1916493755 hasConceptScore W1916493755C2778589496 @default.
- W1916493755 hasConceptScore W1916493755C2779341262 @default.
- W1916493755 hasConceptScore W1916493755C3018697912 @default.
- W1916493755 hasConceptScore W1916493755C51785407 @default.
- W1916493755 hasConceptScore W1916493755C71924100 @default.
- W1916493755 hasConceptScore W1916493755C86803240 @default.
- W1916493755 hasConceptScore W1916493755C8891405 @default.
- W1916493755 hasConceptScore W1916493755C89560881 @default.
- W1916493755 hasLocation W19164937551 @default.
- W1916493755 hasOpenAccess W1916493755 @default.
- W1916493755 hasPrimaryLocation W19164937551 @default.
- W1916493755 hasRelatedWork W2012687954 @default.
- W1916493755 hasRelatedWork W2030306365 @default.
- W1916493755 hasRelatedWork W2040205333 @default.
- W1916493755 hasRelatedWork W2111031906 @default.
- W1916493755 hasRelatedWork W2483597284 @default.
- W1916493755 hasRelatedWork W2522896960 @default.
- W1916493755 hasRelatedWork W2616059824 @default.
- W1916493755 hasRelatedWork W2903564497 @default.
- W1916493755 hasRelatedWork W2958075692 @default.
- W1916493755 hasRelatedWork W2970421739 @default.
- W1916493755 hasRelatedWork W2977320991 @default.
- W1916493755 hasRelatedWork W2994622125 @default.
- W1916493755 hasRelatedWork W3015430657 @default.
- W1916493755 hasRelatedWork W3032220843 @default.
- W1916493755 hasRelatedWork W3096685425 @default.
- W1916493755 hasRelatedWork W3140408403 @default.
- W1916493755 hasRelatedWork W3201842696 @default.
- W1916493755 hasRelatedWork W4206252683 @default.
- W1916493755 hasRelatedWork W4210612718 @default.
- W1916493755 hasRelatedWork W2599797450 @default.
- W1916493755 isParatext "false" @default.
- W1916493755 isRetracted "false" @default.
- W1916493755 magId "1916493755" @default.
- W1916493755 workType "article" @default.