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- W1916580919 abstract "Chlorine (Cl2) is a highly irritant and reactive gas produced in large quantities throughout the world. The accidental release of large amounts of Cl2 in 30 large cities world-wide, caused significant mortality and morbidity to humans and animals. Our previous findings show that exposure of rodent to Cl2 causes both pulmonary and systemic injury (Zarogiannis et al. Am J Respir Cell Mol Biol. 2011;45(2):386-92; Honavar et al.Am J Respir Cell Mol Biol. 201145(2):419-25.) Herein we tested the hypothesis that exposure to Cl2 activates intraalveolar and systemic coagulation cascades which in turn may contribute to the development of lung and other end-organ injury. Male C57Bl/6 mice (6-8 weeks) were exposed to either Cl2 (600 ppm for 45 minutes in environmental chambers) or air (0 ppm). Mice were returned to room air and sacrificed immediately or at 1 h post-exposure and their lungs were lavaged. Mice exposed to Cl2 had much higher levels of Thrombin/anti-Thrombin (TAT) complexes (measured by ELISA) as compared to those exposed to air both in the BAL (10 ± 2 ng/ml vs. 0.5 + 0.1; mean + SE; n=6; p<0.01) and plasma (25±0.1 ng/ml vs. 0.1±0.05; mean + SE; n=6; p<0.01) at 1 h post exposure. In addition clotting time in the blood (measured by thromboelastometry) was significantly prolonged in Cl2 exposed mice as compared with air controls (275 ± 25 sec. vs. 150 2±10; mean + SE; n=6; p<0.01). In contrast, there was no significant change in the clotting time blood taken from mice immediately after Cl2. Taken together, these data demonstrates a strong activation of the coagulation within the airspaces as well as the development of a systemic disseminated intravascular coagulation after Cl2 exposure in mice." @default.
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- W1916580919 date "2012-09-01" @default.
- W1916580919 modified "2023-09-26" @default.
- W1916580919 title "Activation of the coagulation system following exposure of mice to chlorine" @default.
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