Matches in SemOpenAlex for { <https://semopenalex.org/work/W1916693533> ?p ?o ?g. }
- W1916693533 abstract "Stress induced by cytoplasmic protein aggregates can have deleterious consequences for the cell, contributing to neurodegeneration and other diseases. Protein aggregates are also formed within the endoplasmic reticulum (ER), although the fate of ER protein aggregates, specifically during cell division, is not well understood. By simultaneous visualization of both the ER itself and ER protein aggregates, we found that ER protein aggregates that induce ER stress are retained in the mother cell by activation of the ER Stress Surveillance (ERSU) pathway, which prevents inheritance of stressed ER. In contrast, under conditions of normal ER inheritance, ER protein aggregates can enter the daughter cell. Thus, whereas cytoplasmic protein aggregates are retained in the mother cell to protect the functional capacity of daughter cells, the fate of ER protein aggregates is determined by whether or not they activate the ERSU pathway to impede transmission of the cortical ER during the cell cycle." @default.
- W1916693533 created "2016-06-24" @default.
- W1916693533 creator A5030069081 @default.
- W1916693533 creator A5045874120 @default.
- W1916693533 date "2015-09-01" @default.
- W1916693533 modified "2023-09-26" @default.
- W1916693533 title "The ER Stress Surveillance (ERSU) pathway regulates daughter cell ER protein aggregate inheritance" @default.
- W1916693533 cites W120703973 @default.
- W1916693533 cites W1606812696 @default.
- W1916693533 cites W1872122 @default.
- W1916693533 cites W1965816171 @default.
- W1916693533 cites W1966072209 @default.
- W1916693533 cites W1967025628 @default.
- W1916693533 cites W1971622025 @default.
- W1916693533 cites W1975646305 @default.
- W1916693533 cites W1982563652 @default.
- W1916693533 cites W1990146728 @default.
- W1916693533 cites W1990265320 @default.
- W1916693533 cites W1990400035 @default.
- W1916693533 cites W1999746307 @default.
- W1916693533 cites W2000806214 @default.
- W1916693533 cites W2005740500 @default.
- W1916693533 cites W2007422965 @default.
- W1916693533 cites W2008559063 @default.
- W1916693533 cites W2012418095 @default.
- W1916693533 cites W2015357935 @default.
- W1916693533 cites W2017221858 @default.
- W1916693533 cites W2020677693 @default.
- W1916693533 cites W2027430244 @default.
- W1916693533 cites W2029642537 @default.
- W1916693533 cites W2031167624 @default.
- W1916693533 cites W2032710773 @default.
- W1916693533 cites W2038366297 @default.
- W1916693533 cites W2038389268 @default.
- W1916693533 cites W2038395345 @default.
- W1916693533 cites W2045929752 @default.
- W1916693533 cites W2052143537 @default.
- W1916693533 cites W2054791517 @default.
- W1916693533 cites W2062731288 @default.
- W1916693533 cites W2062918974 @default.
- W1916693533 cites W2064157229 @default.
- W1916693533 cites W2067284357 @default.
- W1916693533 cites W2074467340 @default.
- W1916693533 cites W2074743540 @default.
- W1916693533 cites W2075553383 @default.
- W1916693533 cites W2076774576 @default.
- W1916693533 cites W2078039611 @default.
- W1916693533 cites W2080928193 @default.
- W1916693533 cites W2081104776 @default.
- W1916693533 cites W2087566580 @default.
- W1916693533 cites W2087689873 @default.
- W1916693533 cites W2088594374 @default.
- W1916693533 cites W2089198803 @default.
- W1916693533 cites W2092986760 @default.
- W1916693533 cites W2099703166 @default.
- W1916693533 cites W2106983618 @default.
- W1916693533 cites W2109048242 @default.
- W1916693533 cites W2110685895 @default.
- W1916693533 cites W2111591755 @default.
- W1916693533 cites W2114216488 @default.
- W1916693533 cites W2114822038 @default.
- W1916693533 cites W2129498461 @default.
- W1916693533 cites W2135532366 @default.
- W1916693533 cites W2137522359 @default.
- W1916693533 cites W2144750503 @default.
- W1916693533 cites W2146467407 @default.
- W1916693533 cites W2146721676 @default.
- W1916693533 cites W2154164675 @default.
- W1916693533 cites W2155665855 @default.
- W1916693533 cites W2159994070 @default.
- W1916693533 cites W2160182641 @default.
- W1916693533 cites W2169515696 @default.
- W1916693533 cites W2171432169 @default.
- W1916693533 cites W2192080449 @default.
- W1916693533 cites W2275984792 @default.
- W1916693533 doi "https://doi.org/10.7554/elife.06970" @default.
- W1916693533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4555637" @default.
- W1916693533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26327697" @default.
- W1916693533 hasPublicationYear "2015" @default.
- W1916693533 type Work @default.
- W1916693533 sameAs 1916693533 @default.
- W1916693533 citedByCount "17" @default.
- W1916693533 countsByYear W19166935332016 @default.
- W1916693533 countsByYear W19166935332018 @default.
- W1916693533 countsByYear W19166935332019 @default.
- W1916693533 countsByYear W19166935332020 @default.
- W1916693533 countsByYear W19166935332021 @default.
- W1916693533 countsByYear W19166935332022 @default.
- W1916693533 countsByYear W19166935332023 @default.
- W1916693533 crossrefType "journal-article" @default.
- W1916693533 hasAuthorship W1916693533A5030069081 @default.
- W1916693533 hasAuthorship W1916693533A5045874120 @default.
- W1916693533 hasBestOaLocation W19166935331 @default.
- W1916693533 hasConcept C104317684 @default.
- W1916693533 hasConcept C136238340 @default.
- W1916693533 hasConcept C139447449 @default.
- W1916693533 hasConcept C1491633281 @default.
- W1916693533 hasConcept C158617107 @default.
- W1916693533 hasConcept C163952510 @default.
- W1916693533 hasConcept C185592680 @default.