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• W1916759968 abstract "Abstract Intradialytic hypotension (IDH) is one of the most common complications of hemodialysis (HD) treatment. The initiating factor of IDH is a decrease in blood volume, which is related to an imbalance between ultrafiltration (UF) and refilling rate. Impaired reactivity of resistance and capacitance vessels in reaction to hypovolemia plays possibly a major role in the occurrence of IDH. These vessels also fulfill an important function in body temperature regulation. UF‐induced cutaneous vasoconstriction would result in a reduced surface heat loss and an increase in core temperature. To release body heat, skin blood flow is increased at a later stage of the HD treatment, whereby possibly IDH can occur. The aim of the study is to develop a mathematical model that can provide insight into the impact of thermoregulatory processes on the cardiovascular (CV) system during HD treatment. The mathematical procedure has been created by coupling a thermo‐physiological model with a CV model to study regulation mechanisms in the human body during HD + UF. Model simulations for isothermal versus thermoneutral HD + UF were compared with measurement data of patients on chronic intermittent HD ( n = 13). Core temperature during simulated HD + UF sessions increased within the range of measurement data (0.23°C vs. 0.32 ± 0.41°C). The model showed a decline in mean arterial pressure of −7% for thermoneutral HD + UF versus −4% for isothermal HD + UF after 200 min during which relative blood volume changed by −13%. In conclusion, simulation results of the combined model show possibilities for predicting circulatory and thermal responses during HD + UF." @default.
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• W1916759968 date "2012-07-02" @default.
• W1916759968 modified "2023-10-17" @default.
• W1916759968 title "Mathematical Modeling of Thermal and Circulatory Effects During Hemodialysis" @default.
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• W1916759968 doi "https://doi.org/10.1111/j.1525-1594.2012.01464.x" @default.
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