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- W1916853670 abstract "Adenophora triphylla var. japonica (Campanulaceae) is known to have anti‐inflammatory and anti‐tussive effects. Dysfunction of adipocytes and adipose tissue in obesity is related to various inflammatory cytokines or adipokines. In this study, we investigated whether lupenone isolated from A. triphylla var. japonica extract inhibits adipocyte differentiation and expression of adipogenic marker genes in 3T3‐L1 preadipocytes. We demonstrated that lupenone resulted in a significant reduction in lipid accumulation and expression of adipogenic marker genes in a dose‐dependent manner. In addition, lupenone decreased the transcriptional activity of peroxisome proliferator‐activated receptor γ (PPARγ) induced by troglitazone, and we also demonstrated that lupenone suppressed the PPARγ and CCAAT‐enhancer‐binding protein α (C/EBPα) protein levels. These findings demonstrated that lupenone isolated from A. triphylla var. japonica extract effectively inhibited adipocyte differentiation through downregulation of related transcription factor, particularly the PPARγ gene. Copyright © 2012 John Wiley & Sons, Ltd." @default.
- W1916853670 created "2016-06-24" @default.
- W1916853670 creator A5017506857 @default.
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- W1916853670 date "2012-07-31" @default.
- W1916853670 modified "2023-10-17" @default.
- W1916853670 title "Lupenone Isolated from<i>Adenophora triphylla</i>var.<i>japonica</i>Extract Inhibits Adipogenic Differentiation through the Downregulation of PPARγ in 3T3-L1 Cells" @default.
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- W1916853670 doi "https://doi.org/10.1002/ptr.4779" @default.
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