FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1916865995> ?p ?o ?g. }

• W1916865995 abstract "PURPOSE: To evaluate the safety and hematopoietic activity of daniplestim administered concurrently with granulocyte colony-stimulating factor (G-CSF) for peripheral-blood stem-cell (PBSC) mobilization. PATIENTS AND METHODS: In the initial dose-escalation phase, 25 patients with adenocarcinoma of the breast (AB; 13 patients) or lymphoma (12 patients) were given daniplestim at doses ranging from 0.1 to 3.75 μg/kg/d plus G-CSF 10 μg/kg/d. In the randomized phase, 52 patients with AB (27 patients) or lymphoma (25 patients) were randomized within disease categories to the daniplestim dose chosen in the dose-escalation phase plus G-CSF 10 μg/kg/d (D+G) or placebo plus G-CSF 10 μg/kg/d (P+G) for up to 7 days. RESULTS: A daniplestim dose of 2.5 μg/kg/d was chosen for further study because it was hematopoietically active and had an acceptable side-effect profile. In the randomized phase, in patients with AB, D+G was associated with a higher probability (P = .0696) of collecting ≥ 2.5 × 10 6 CD34 + cells/kg and significantly higher circulating CD34 + cell counts (P = .0498) on days 6 through 9 after the initiation of dosing. The target level was more likely to be reached with additional leukaphereses in the patients given D+G. Patients given P+G did not benefit from additional leukaphereses beyond the first procedure. The type of mobilization did show a trend toward a shorter duration of neutropenia in the D+G group. The adverse events with D+G consisted largely of mild to moderate flu-like symptoms, including headache and fever, and occurred more frequently than with P+G. CONCLUSION: Daniplestim administered at 2.5 μg/kg/d is tolerable and active when combined with G-CSF, and the combination may prove more effective than G-CSF alone in promoting the collection of adequate numbers of CD34 + cells for PBSC infusion in patients with AB." @default.
• W1916865995 created "2016-06-24" @default.
• W1916865995 creator A5003670546 @default.
• W1916865995 creator A5029569818 @default.
• W1916865995 creator A5041307140 @default.
• W1916865995 creator A5051363304 @default.
• W1916865995 creator A5058625232 @default.
• W1916865995 creator A5065066309 @default.
• W1916865995 creator A5068001475 @default.
• W1916865995 creator A5076686164 @default.
• W1916865995 date "2000-07-14" @default.
• W1916865995 modified "2023-09-26" @default.
• W1916865995 title "Mobilization of Peripheral-Blood Stem Cells by Concurrent Administration of Daniplestim and Granulocyte Colony-Stimulating Factor in Patients With Breast Cancer or Lymphoma" @default.
• W1916865995 cites W1520461053 @default.
• W1916865995 cites W1526986700 @default.
• W1916865995 cites W1532162953 @default.
• W1916865995 cites W1549719455 @default.
• W1916865995 cites W159629284 @default.
• W1916865995 cites W186453261 @default.
• W1916865995 cites W1881943990 @default.
• W1916865995 cites W1924642125 @default.
• W1916865995 cites W1962943827 @default.
• W1916865995 cites W1965466579 @default.
• W1916865995 cites W1988068150 @default.
• W1916865995 cites W1989695461 @default.
• W1916865995 cites W2020751729 @default.
• W1916865995 cites W2029534940 @default.
• W1916865995 cites W2031886326 @default.
• W1916865995 cites W2040719183 @default.
• W1916865995 cites W2045027597 @default.
• W1916865995 cites W2050437518 @default.
• W1916865995 cites W2051320020 @default.
• W1916865995 cites W2062729668 @default.
• W1916865995 cites W2071595697 @default.
• W1916865995 cites W2075299924 @default.
• W1916865995 cites W2088310945 @default.
• W1916865995 cites W2117649239 @default.
• W1916865995 cites W2121033804 @default.
• W1916865995 cites W2121763019 @default.
• W1916865995 cites W2121960093 @default.
• W1916865995 cites W2125887123 @default.
• W1916865995 cites W2127524453 @default.
• W1916865995 cites W2129313216 @default.
• W1916865995 cites W2168725395 @default.
• W1916865995 cites W2170642087 @default.
• W1916865995 cites W2259965498 @default.
• W1916865995 cites W2293996838 @default.
• W1916865995 cites W2400775309 @default.
• W1916865995 cites W2410725147 @default.
• W1916865995 cites W2411716823 @default.
• W1916865995 cites W2413624788 @default.
• W1916865995 cites W2414498087 @default.
• W1916865995 cites W2416824725 @default.
• W1916865995 cites W2416876205 @default.
• W1916865995 cites W2474870784 @default.
• W1916865995 cites W48615449 @default.
• W1916865995 cites W92846538 @default.
• W1916865995 cites W93037232 @default.
• W1916865995 doi "https://doi.org/10.1200/jco.2000.18.14.2762" @default.
• W1916865995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10894877" @default.
• W1916865995 hasPublicationYear "2000" @default.
• W1916865995 type Work @default.
• W1916865995 sameAs 1916865995 @default.
• W1916865995 citedByCount "11" @default.
• W1916865995 countsByYear W19168659952012 @default.
• W1916865995 countsByYear W19168659952013 @default.
• W1916865995 countsByYear W19168659952017 @default.
• W1916865995 crossrefType "journal-article" @default.
• W1916865995 hasAuthorship W1916865995A5003670546 @default.
• W1916865995 hasAuthorship W1916865995A5029569818 @default.
• W1916865995 hasAuthorship W1916865995A5041307140 @default.
• W1916865995 hasAuthorship W1916865995A5051363304 @default.
• W1916865995 hasAuthorship W1916865995A5058625232 @default.
• W1916865995 hasAuthorship W1916865995A5065066309 @default.
• W1916865995 hasAuthorship W1916865995A5068001475 @default.
• W1916865995 hasAuthorship W1916865995A5076686164 @default.
• W1916865995 hasConcept C109159458 @default.
• W1916865995 hasConcept C121608353 @default.
• W1916865995 hasConcept C126322002 @default.
• W1916865995 hasConcept C142724271 @default.
• W1916865995 hasConcept C204787440 @default.
• W1916865995 hasConcept C27081682 @default.
• W1916865995 hasConcept C2776694085 @default.
• W1916865995 hasConcept C2777767877 @default.
• W1916865995 hasConcept C2779338263 @default.
• W1916865995 hasConcept C2779958370 @default.
• W1916865995 hasConcept C28328180 @default.
• W1916865995 hasConcept C530470458 @default.
• W1916865995 hasConcept C54355233 @default.
• W1916865995 hasConcept C71924100 @default.
• W1916865995 hasConcept C86803240 @default.
• W1916865995 hasConcept C90924648 @default.
• W1916865995 hasConceptScore W1916865995C109159458 @default.
• W1916865995 hasConceptScore W1916865995C121608353 @default.
• W1916865995 hasConceptScore W1916865995C126322002 @default.
• W1916865995 hasConceptScore W1916865995C142724271 @default.
• W1916865995 hasConceptScore W1916865995C204787440 @default.
• W1916865995 hasConceptScore W1916865995C27081682 @default.
• W1916865995 hasConceptScore W1916865995C2776694085 @default.
• W1916865995 hasConceptScore W1916865995C2777767877 @default.

• next