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- W1916946492 abstract "The metabolic requirements of cancer cells differ from that of their normal counterparts. To support their proliferation, cancer cells switch to a fermentative metabolism that is thought to support biomass production. Instances where metabolic enzymes promote tumorigenesis remain rare. However, an enzyme involved in the de novo synthesis of serine, 3-phosphoglycerate dehydrogenase (PHGDH), was recently identified as a putative oncogene. The potential mechanisms by which PHGDH promotes cancer are discussed." @default.
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- W1916946492 date "2011-10-28" @default.
- W1916946492 modified "2023-10-17" @default.
- W1916946492 title "PHGDH amplification and altered glucose metabolism in human melanoma" @default.
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- W1916946492 doi "https://doi.org/10.1111/j.1755-148x.2011.00919.x" @default.
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