Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917044539> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1917044539 endingPage "28" @default.
- W1917044539 startingPage "11" @default.
- W1917044539 abstract "Abstract Using a screen that directly assesses transductional proficiency, we have isolated suppressors of recB mutations in Salmonella typhimurium. The alleles of sbcB reported here are phenotypically distinct from those isolated in Escherichia coli in that they restore recombination proficiency (Rec+), resistance to ultraviolet light (UVR), and mitomycin C resistance (MCR) in the absence of an accompanying sbcCD mutation. In addition the sbcB alleles reported here are co-dominant to sbcB+. We have also isolated insertion and deletion mutants of the sbcB locus. These null mutations suppress only the UVS phenotype of recB mutants. We have also isolated sbcCD mutations, which map near proC. These sbcCD mutations increase the viability, recombination proficiency and MCR of both the transductional recombination suppressors (sbcB1 & sbcB6) and the sbcB null mutations. S. typhimurium recB sbcB1 sbcCD8 strains are 15-fold more recombination proficient than wild-type strains. The increase in transductants in these strains is accompanied by a loss of abortive transductants suggesting that these fragments are accessible to the mutant recombination apparatus. Using tandem duplications, we have constructed sbcB merodiploids and found that, in a recB mutant sbcCD+ genetic background, the sbcB+ allele is dominant to sbcB1 for transductional recombination but co-dominant for UVR and MCR. However, in a recB sbcCD8 genetic background, the sbcB1 mutation is co-dominant to sbcB+ for all phenotypes. Our results lead us to suggest that the SbcB and SbcCD proteins have roles in RecBCD-dependent recombination." @default.
- W1917044539 created "2016-06-24" @default.
- W1917044539 creator A5005774025 @default.
- W1917044539 creator A5062133521 @default.
- W1917044539 date "1994-09-01" @default.
- W1917044539 modified "2023-10-18" @default.
- W1917044539 title "Suppressors of recB mutations in Salmonella typhimurium." @default.
- W1917044539 cites W1487898062 @default.
- W1917044539 cites W1531202304 @default.
- W1917044539 cites W1546783991 @default.
- W1917044539 cites W1554627281 @default.
- W1917044539 cites W1851648683 @default.
- W1917044539 cites W1906848714 @default.
- W1917044539 cites W1913367356 @default.
- W1917044539 cites W1964268778 @default.
- W1917044539 cites W2020438473 @default.
- W1917044539 cites W2032614625 @default.
- W1917044539 cites W2035179579 @default.
- W1917044539 cites W2060295978 @default.
- W1917044539 cites W2064600419 @default.
- W1917044539 cites W2073534733 @default.
- W1917044539 cites W2110350081 @default.
- W1917044539 cites W2120368575 @default.
- W1917044539 cites W2124258547 @default.
- W1917044539 cites W2128561000 @default.
- W1917044539 cites W2134768908 @default.
- W1917044539 cites W2174274173 @default.
- W1917044539 doi "https://doi.org/10.1093/genetics/138.1.11" @default.
- W1917044539 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1206122" @default.
- W1917044539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8001778" @default.
- W1917044539 hasPublicationYear "1994" @default.
- W1917044539 type Work @default.
- W1917044539 sameAs 1917044539 @default.
- W1917044539 citedByCount "15" @default.
- W1917044539 crossrefType "journal-article" @default.
- W1917044539 hasAuthorship W1917044539A5005774025 @default.
- W1917044539 hasAuthorship W1917044539A5062133521 @default.
- W1917044539 hasBestOaLocation W19170445391 @default.
- W1917044539 hasConcept C104317684 @default.
- W1917044539 hasConcept C143065580 @default.
- W1917044539 hasConcept C153911025 @default.
- W1917044539 hasConcept C156695909 @default.
- W1917044539 hasConcept C174742784 @default.
- W1917044539 hasConcept C180754005 @default.
- W1917044539 hasConcept C54355233 @default.
- W1917044539 hasConcept C547475151 @default.
- W1917044539 hasConcept C86803240 @default.
- W1917044539 hasConceptScore W1917044539C104317684 @default.
- W1917044539 hasConceptScore W1917044539C143065580 @default.
- W1917044539 hasConceptScore W1917044539C153911025 @default.
- W1917044539 hasConceptScore W1917044539C156695909 @default.
- W1917044539 hasConceptScore W1917044539C174742784 @default.
- W1917044539 hasConceptScore W1917044539C180754005 @default.
- W1917044539 hasConceptScore W1917044539C54355233 @default.
- W1917044539 hasConceptScore W1917044539C547475151 @default.
- W1917044539 hasConceptScore W1917044539C86803240 @default.
- W1917044539 hasIssue "1" @default.
- W1917044539 hasLocation W19170445391 @default.
- W1917044539 hasLocation W19170445392 @default.
- W1917044539 hasOpenAccess W1917044539 @default.
- W1917044539 hasPrimaryLocation W19170445391 @default.
- W1917044539 hasRelatedWork W1618203808 @default.
- W1917044539 hasRelatedWork W1678475228 @default.
- W1917044539 hasRelatedWork W1747540615 @default.
- W1917044539 hasRelatedWork W1928656130 @default.
- W1917044539 hasRelatedWork W1974016379 @default.
- W1917044539 hasRelatedWork W1976856826 @default.
- W1917044539 hasRelatedWork W1981569373 @default.
- W1917044539 hasRelatedWork W1994932288 @default.
- W1917044539 hasRelatedWork W2002333699 @default.
- W1917044539 hasRelatedWork W2032614625 @default.
- W1917044539 hasRelatedWork W2063885377 @default.
- W1917044539 hasRelatedWork W2073534733 @default.
- W1917044539 hasRelatedWork W2075856977 @default.
- W1917044539 hasRelatedWork W2082995057 @default.
- W1917044539 hasRelatedWork W2110350081 @default.
- W1917044539 hasRelatedWork W2142706945 @default.
- W1917044539 hasRelatedWork W2145304961 @default.
- W1917044539 hasRelatedWork W2188046322 @default.
- W1917044539 hasRelatedWork W2221515008 @default.
- W1917044539 hasRelatedWork W2474633822 @default.
- W1917044539 hasVolume "138" @default.
- W1917044539 isParatext "false" @default.
- W1917044539 isRetracted "false" @default.
- W1917044539 magId "1917044539" @default.
- W1917044539 workType "article" @default.