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• W1917101778 endingPage "1006" @default.
• W1917101778 startingPage "993" @default.
• W1917101778 abstract "Epstein-Barr virus (EBV) latent infection of B cells blocks the interrelated signaling and antigen-trafficking functions of the BCR through the activity of its latent membrane protein 2A (LMP2A). At present, the molecular mechanisms by which LMP2A exerts its control of BCR functions are only poorly understood. Earlier studies showed that in B cells expressing LMP2A containing a tyrosine mutation at position 112 in its cytoplasmic domain (Y112-LMP2A), the BCR could initiate signaling but could not properly traffic antigen for processing. Here, we show that BCR signaling in Y112-LMP2A-expressing cells is attenuated with a reduction in both the degree and duration of phosphorylation of key components of the BCR signaling cascade including Syk, BLNK, PI3K, and Btk. Notably, Y112-LMP2A expression completely blocked the BCR-induced activation of phospholipase D (PLD), a lipase implicated in the intracellular trafficking of a variety of surface receptors. We show that blocking PLD activity, by expressing Y112-LMP2A, treating cells with the PLD inhibitor 1-butanol or reducing PLD expression by siRNA, blocked BCR trafficking to class II-containing compartments. Moreover, Y112-LMP2A expression blocked the recruitment of phosphorylated forms of the downstream BCR signaling components, Erk and JNK, through both PLD-dependent and PLD-independent mechanisms. Thus, the investigation of the mechanism by which Y112-LMP2A blocks BCR function revealed an essential role for PLD in BCR trafficking for antigen processing." @default.
• W1917101778 created "2016-06-24" @default.
• W1917101778 creator A5025853358 @default.
• W1917101778 creator A5054727819 @default.
• W1917101778 date "2006-06-08" @default.
• W1917101778 modified "2023-10-18" @default.
• W1917101778 title "A Mutation in Epstein-Barr Virus LMP2A Reveals a Role for Phospholipase D in B-Cell Antigen Receptor Trafficking" @default.
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• W1917101778 doi "https://doi.org/10.1111/j.1600-0854.2006.00450.x" @default.
• W1917101778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16882041" @default.
• W1917101778 hasPublicationYear "2006" @default.

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