FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917144620> ?p ?o ?g. }

• W1917144620 endingPage "1307" @default.
• W1917144620 startingPage "1301" @default.
• W1917144620 abstract "The interaction between peptidergic, sensory nerves and sympathetic fibers was examined in the rat iris. The putative peptide neurotransmitter, substance P, was used as an index of the sensory innervation, because the peptide is exclusively localized in the iris to trigeminal sensory fibers. Extirpation of the sympathetic, superior cervical ganglion resulted in an increase in iris content of substance P-like immunoreactivity (henceforth SP), suggesting that sympathetic terminals influence the peptidergic sensory innervation of the iris. The increase in iris peptide after sympathetic ganglionectomy was reversed by implantation of sympathetic ganglia into the anterior chamber of the eye. Pharmacological stimulation or blockade of sympathetic nerve impulse activity and pharmacological blockade of sympathetic axonal transport did not alter iris peptide, suggesting that these procedures did not mediate the sympathetic-sensory interaction. However, injection of nerve growth factor (NGF) systemically or into the anterior chamber increased iris peptide, reproducing the effects of ganglionectomy. Conversely, injection of antiserum to NGF (anti-NGF) into the anterior chamber decreased iris SP suggesting that endogenous trophic protein normally regulates sensory peptide. The effects of anti-NGF were transitory; iris peptide returned to normal after cessation of treatment. Consequently, anti-NGF administration apparently did not lead to sensory neuron destruction, but rather altered either the number of sensory fibers in the iris or the amount of peptide per fiber. Finally, injection of anti-NGF into the anterior chamber reversed the effects of sympathetic ganglionectomy, suggesting that NGF may mediate the sympathetic-sensory interaction. Our observations suggest that competition for target NGF may result in reciprocal regulation of the iris sympathetic and sensory innervation." @default.
• W1917144620 created "2016-06-24" @default.
• W1917144620 creator A5021467671 @default.
• W1917144620 creator A5026655827 @default.
• W1917144620 creator A5044536478 @default.
• W1917144620 date "1983-06-01" @default.
• W1917144620 modified "2023-09-26" @default.
• W1917144620 title "Interactions between the sympathetic and sensory innervation of the iris" @default.
• W1917144620 cites W162336345 @default.
• W1917144620 cites W1969388576 @default.
• W1917144620 cites W1983441282 @default.
• W1917144620 cites W1983933746 @default.
• W1917144620 cites W1997610262 @default.
• W1917144620 cites W2003378719 @default.
• W1917144620 cites W2012923655 @default.
• W1917144620 cites W2017865805 @default.
• W1917144620 cites W2037270752 @default.
• W1917144620 cites W2037351441 @default.
• W1917144620 cites W2067313865 @default.
• W1917144620 cites W2068831147 @default.
• W1917144620 cites W2077992364 @default.
• W1917144620 cites W2081684819 @default.
• W1917144620 cites W2093749821 @default.
• W1917144620 cites W2143987120 @default.
• W1917144620 cites W2162010149 @default.
• W1917144620 cites W2188209719 @default.
• W1917144620 doi "https://doi.org/10.1523/jneurosci.03-06-01301.1983" @default.
• W1917144620 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6564601" @default.
• W1917144620 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6189983" @default.
• W1917144620 hasPublicationYear "1983" @default.
• W1917144620 type Work @default.
• W1917144620 sameAs 1917144620 @default.
• W1917144620 citedByCount "142" @default.
• W1917144620 countsByYear W19171446202013 @default.
• W1917144620 countsByYear W19171446202014 @default.
• W1917144620 countsByYear W19171446202015 @default.
• W1917144620 countsByYear W19171446202023 @default.
• W1917144620 crossrefType "journal-article" @default.
• W1917144620 hasAuthorship W1917144620A5021467671 @default.
• W1917144620 hasAuthorship W1917144620A5026655827 @default.
• W1917144620 hasAuthorship W1917144620A5044536478 @default.
• W1917144620 hasBestOaLocation W19171446201 @default.
• W1917144620 hasConcept C126322002 @default.
• W1917144620 hasConcept C134018914 @default.
• W1917144620 hasConcept C142724271 @default.
• W1917144620 hasConcept C169760540 @default.
• W1917144620 hasConcept C170493617 @default.
• W1917144620 hasConcept C204787440 @default.
• W1917144620 hasConcept C24998067 @default.
• W1917144620 hasConcept C2775907655 @default.
• W1917144620 hasConcept C2776352249 @default.
• W1917144620 hasConcept C2776533406 @default.
• W1917144620 hasConcept C2776650652 @default.
• W1917144620 hasConcept C2778423431 @default.
• W1917144620 hasConcept C2778993773 @default.
• W1917144620 hasConcept C2779190097 @default.
• W1917144620 hasConcept C71924100 @default.
• W1917144620 hasConcept C84393581 @default.
• W1917144620 hasConcept C86803240 @default.
• W1917144620 hasConcept C94487597 @default.
• W1917144620 hasConceptScore W1917144620C126322002 @default.
• W1917144620 hasConceptScore W1917144620C134018914 @default.
• W1917144620 hasConceptScore W1917144620C142724271 @default.
• W1917144620 hasConceptScore W1917144620C169760540 @default.
• W1917144620 hasConceptScore W1917144620C170493617 @default.
• W1917144620 hasConceptScore W1917144620C204787440 @default.
• W1917144620 hasConceptScore W1917144620C24998067 @default.
• W1917144620 hasConceptScore W1917144620C2775907655 @default.
• W1917144620 hasConceptScore W1917144620C2776352249 @default.
• W1917144620 hasConceptScore W1917144620C2776533406 @default.
• W1917144620 hasConceptScore W1917144620C2776650652 @default.
• W1917144620 hasConceptScore W1917144620C2778423431 @default.
• W1917144620 hasConceptScore W1917144620C2778993773 @default.
• W1917144620 hasConceptScore W1917144620C2779190097 @default.
• W1917144620 hasConceptScore W1917144620C71924100 @default.
• W1917144620 hasConceptScore W1917144620C84393581 @default.
• W1917144620 hasConceptScore W1917144620C86803240 @default.
• W1917144620 hasConceptScore W1917144620C94487597 @default.
• W1917144620 hasIssue "6" @default.
• W1917144620 hasLocation W19171446201 @default.
• W1917144620 hasLocation W19171446202 @default.
• W1917144620 hasLocation W19171446203 @default.
• W1917144620 hasLocation W19171446204 @default.
• W1917144620 hasLocation W19171446205 @default.
• W1917144620 hasOpenAccess W1917144620 @default.
• W1917144620 hasPrimaryLocation W19171446201 @default.
• W1917144620 hasRelatedWork W1917144620 @default.
• W1917144620 hasRelatedWork W1990717467 @default.
• W1917144620 hasRelatedWork W2046401998 @default.
• W1917144620 hasRelatedWork W2057294553 @default.
• W1917144620 hasRelatedWork W2082976606 @default.
• W1917144620 hasRelatedWork W2083092596 @default.
• W1917144620 hasRelatedWork W2091435623 @default.
• W1917144620 hasRelatedWork W2352185812 @default.
• W1917144620 hasRelatedWork W4310583562 @default.
• W1917144620 hasRelatedWork W4311158820 @default.
• W1917144620 hasVolume "3" @default.
• W1917144620 isParatext "false" @default.

• next