Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917261668> ?p ?o ?g. }
- W1917261668 endingPage "1581" @default.
- W1917261668 startingPage "1567" @default.
- W1917261668 abstract "Obtaining an effective antimalarial vaccine has represented one of the biggest public health challenges over the last 50 years. Despite efforts by many laboratories around the world using whole-organism, recombinant proteins and genome-based approaches, the results have been disappointing. One of the main problems when designing an antimalarial vaccine is the poor immunogenicity induced by the functionally relevant and conserved protein regions of the parasite.This review focuses on the logical and rational methodology followed to identify Plasmodium falciparum conserved functional regions with the ability to bind to target cells conserved high activity binding peptides (cHABPs) and the physicochemical and immunological characteristics that should be taken into account for modifying them into highly immunogenic and protection-inducing peptides (mHABPs) into highly immunogenic and protection-inducing in Aotus monkeys.The functional approach taken to develop a fully protective, minimal subunit-based, multiantigenic, multistage and synthetic peptide-based antimalarial vaccine has shown promising results. The clear relationship observed between mHABPs structure and their immunological properties highlights the challenges and opportunities arising from this methodology, as well as the universal principles and rules derived therefrom." @default.
- W1917261668 created "2016-06-24" @default.
- W1917261668 creator A5019790423 @default.
- W1917261668 creator A5042652382 @default.
- W1917261668 date "2015-08-04" @default.
- W1917261668 modified "2023-09-26" @default.
- W1917261668 title "Recent advances in the development of a chemically synthesised anti-malarial vaccine" @default.
- W1917261668 cites W1836213700 @default.
- W1917261668 cites W1882915604 @default.
- W1917261668 cites W1939795561 @default.
- W1917261668 cites W1964145672 @default.
- W1917261668 cites W1966914670 @default.
- W1917261668 cites W1971592544 @default.
- W1917261668 cites W1972053203 @default.
- W1917261668 cites W1972512154 @default.
- W1917261668 cites W1973541716 @default.
- W1917261668 cites W1977081616 @default.
- W1917261668 cites W1980273151 @default.
- W1917261668 cites W1984101452 @default.
- W1917261668 cites W1986116104 @default.
- W1917261668 cites W1986570534 @default.
- W1917261668 cites W1990285073 @default.
- W1917261668 cites W1992874892 @default.
- W1917261668 cites W1992999474 @default.
- W1917261668 cites W1997335770 @default.
- W1917261668 cites W1997659370 @default.
- W1917261668 cites W1997828001 @default.
- W1917261668 cites W2007664717 @default.
- W1917261668 cites W2010837749 @default.
- W1917261668 cites W2014295739 @default.
- W1917261668 cites W2018620812 @default.
- W1917261668 cites W2018858007 @default.
- W1917261668 cites W2018984543 @default.
- W1917261668 cites W2025326880 @default.
- W1917261668 cites W2026615530 @default.
- W1917261668 cites W2027561555 @default.
- W1917261668 cites W2031215290 @default.
- W1917261668 cites W2031383147 @default.
- W1917261668 cites W2034694458 @default.
- W1917261668 cites W2035645815 @default.
- W1917261668 cites W2037096068 @default.
- W1917261668 cites W2037653306 @default.
- W1917261668 cites W2040791477 @default.
- W1917261668 cites W2040840100 @default.
- W1917261668 cites W2042022433 @default.
- W1917261668 cites W2042744752 @default.
- W1917261668 cites W2042758260 @default.
- W1917261668 cites W2042808979 @default.
- W1917261668 cites W2043745393 @default.
- W1917261668 cites W2044263831 @default.
- W1917261668 cites W2049551663 @default.
- W1917261668 cites W2053124485 @default.
- W1917261668 cites W2054512413 @default.
- W1917261668 cites W2054884020 @default.
- W1917261668 cites W2056189816 @default.
- W1917261668 cites W2056624347 @default.
- W1917261668 cites W2056877576 @default.
- W1917261668 cites W2060439137 @default.
- W1917261668 cites W2060695158 @default.
- W1917261668 cites W2063014826 @default.
- W1917261668 cites W2063337304 @default.
- W1917261668 cites W2063517890 @default.
- W1917261668 cites W2064381894 @default.
- W1917261668 cites W2064949048 @default.
- W1917261668 cites W2071640643 @default.
- W1917261668 cites W2072500217 @default.
- W1917261668 cites W2072778373 @default.
- W1917261668 cites W2074222872 @default.
- W1917261668 cites W2077553393 @default.
- W1917261668 cites W2079688453 @default.
- W1917261668 cites W2080764441 @default.
- W1917261668 cites W2080910844 @default.
- W1917261668 cites W2080956086 @default.
- W1917261668 cites W2082729236 @default.
- W1917261668 cites W2082762936 @default.
- W1917261668 cites W2083753880 @default.
- W1917261668 cites W2084534043 @default.
- W1917261668 cites W2085831528 @default.
- W1917261668 cites W2087528731 @default.
- W1917261668 cites W2087887333 @default.
- W1917261668 cites W2087944044 @default.
- W1917261668 cites W2089008531 @default.
- W1917261668 cites W2090678951 @default.
- W1917261668 cites W2094215362 @default.
- W1917261668 cites W2094954825 @default.
- W1917261668 cites W2097419199 @default.
- W1917261668 cites W2101866299 @default.
- W1917261668 cites W2102137601 @default.
- W1917261668 cites W2102938736 @default.
- W1917261668 cites W2108522714 @default.
- W1917261668 cites W2109289401 @default.
- W1917261668 cites W2112336729 @default.
- W1917261668 cites W2114957284 @default.
- W1917261668 cites W2115494696 @default.
- W1917261668 cites W2119855808 @default.
- W1917261668 cites W2124303795 @default.
- W1917261668 cites W2128813386 @default.
- W1917261668 cites W2133704481 @default.