FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917320814> ?p ?o ?g. }

• W1917320814 endingPage "709" @default.
• W1917320814 startingPage "703" @default.
• W1917320814 abstract "Glucuronidation은 NNAL [4-(methylnitrosamno)-1-(3-pyridyl)-1-butanol]의 주요 pathway이며, UGT2B의 family인 UGT2B17 (UGT, uridine diphospho-glucuronosyltransferase) 유전자는 발암원의 glucuronidation에 관여 한다. UGT2B17 결손은 NNAL의 감소 수준과 특정 암에 있어 위험도를 증가시킨다. UGT2B17 유전자의 copy 수는 사람에서 개인별로 0~2로 다양하다. 본 연구에서는 UGT2B17 결손이 폐암의 위험도와 연관성을 가지는 가를 알아보기 위해 한국인인 271명의 대조군과 176명의 폐암환자의 샘플로 PCR 방법으로 CNV를 조사하였다. 그 결과, 현재까지 보고된 백인과 흑인에 비해 한국인에서 결실 대립형질이 현저히 높게 나타났다. 백인에서 유전자 두 개 모두가 결실된 0 copy 수가 약 10%를 나타낸 것에 비해, 본 연구의 한국인에서는 0 copy 수가 약 74%를 나타내었다. 더욱이 양 쪽 결실이 여성그룹에서 전반적으로 남성그룹에 비해 높게 나타났다. 그러나 UGT2B17 유전자가 CNV와 폐암과의 연관성은 찾을 수 없었다. 이러한 결과는 UGT2B17 유전자의 결실이 폐암의 감수성과는 연관되어 있지 않으나, UGT2B17 CNV 다형성이 인종간의 진화적 분석의 유용한 마커로 사용이 가능할 것으로 사료된다. Glucuronidation is a major pathway for NNAL [4-(methylnitrosamno)-1-(3-pyridyl)-1-butanol] and UGT2B17 (UGT, uridine diphospho-glucuronosyltransferase) is from the UGT2B family that glucuronidates carcinogens. UGT2B17 deletion was associated with decreased levels of NNAL and with increased risk of some cancers. The UGT2B17 gene varies in copy number from zero to two per individual in humans. To examine whether UGT2B17 gene deletion is associated with the risk of lung cancer, we investigated copy number variants (CNV) in 271 cancer-free controls and 176 cases of lung cancer in Koreans by a PCR-based method. The frequency of the UGT2B17 deleted alleles was much higher than in other Caucasian and African-American groups which have already been reported. While only up to 10% of Caucasians have zero copies of the gene, up to 74% of Koreans in this study showed that both copies of the gene were deleted. Furthermore, the overall frequency of this dual deletion in female groups was higher than in male groups. However, there was no association between CNV in UGT2B17 and lung cancer. This result suggested that the UGT2B17 deletion allele was not associated with the susceptibility of lung cancers in the Korean group. However, this UGT2B17 CNV polymorphism may be a useful marker for evolutionary analysis among races." @default.
• W1917320814 created "2016-06-24" @default.
• W1917320814 date "2010-05-30" @default.
• W1917320814 modified "2023-10-16" @default.
• W1917320814 title "Deletion Polymorphism of UGT2B17 and Its Relation to Lung Cancer" @default.
• W1917320814 cites W1965516808 @default.
• W1917320814 cites W1970246008 @default.
• W1917320814 cites W1972504152 @default.
• W1917320814 cites W1977052256 @default.
• W1917320814 cites W1977475884 @default.
• W1917320814 cites W1981026088 @default.
• W1917320814 cites W1995727180 @default.
• W1917320814 cites W2041804792 @default.
• W1917320814 cites W2047893575 @default.
• W1917320814 cites W2061587734 @default.
• W1917320814 cites W2073166174 @default.
• W1917320814 cites W2084499815 @default.
• W1917320814 cites W2091496356 @default.
• W1917320814 cites W2093951074 @default.
• W1917320814 cites W2104218121 @default.
• W1917320814 cites W2105089690 @default.
• W1917320814 cites W2120869094 @default.
• W1917320814 cites W2126040395 @default.
• W1917320814 cites W2132804094 @default.
• W1917320814 cites W2133109906 @default.
• W1917320814 cites W2157300539 @default.
• W1917320814 cites W2162504881 @default.
• W1917320814 cites W2164800045 @default.
• W1917320814 doi "https://doi.org/10.5352/jls.2010.20.5.703" @default.
• W1917320814 hasPublicationYear "2010" @default.
• W1917320814 type Work @default.
• W1917320814 sameAs 1917320814 @default.
• W1917320814 citedByCount "2" @default.
• W1917320814 countsByYear W19173208142015 @default.
• W1917320814 countsByYear W19173208142019 @default.
• W1917320814 crossrefType "journal-article" @default.
• W1917320814 hasBestOaLocation W19173208141 @default.
• W1917320814 hasConcept C104317684 @default.
• W1917320814 hasConcept C120821319 @default.
• W1917320814 hasConcept C126322002 @default.
• W1917320814 hasConcept C141231307 @default.
• W1917320814 hasConcept C180754005 @default.
• W1917320814 hasConcept C202751555 @default.
• W1917320814 hasConcept C2776256026 @default.
• W1917320814 hasConcept C2779907587 @default.
• W1917320814 hasConcept C2781278898 @default.
• W1917320814 hasConcept C54355233 @default.
• W1917320814 hasConcept C71924100 @default.
• W1917320814 hasConcept C86803240 @default.
• W1917320814 hasConcept C87644729 @default.
• W1917320814 hasConceptScore W1917320814C104317684 @default.
• W1917320814 hasConceptScore W1917320814C120821319 @default.
• W1917320814 hasConceptScore W1917320814C126322002 @default.
• W1917320814 hasConceptScore W1917320814C141231307 @default.
• W1917320814 hasConceptScore W1917320814C180754005 @default.
• W1917320814 hasConceptScore W1917320814C202751555 @default.
• W1917320814 hasConceptScore W1917320814C2776256026 @default.
• W1917320814 hasConceptScore W1917320814C2779907587 @default.
• W1917320814 hasConceptScore W1917320814C2781278898 @default.
• W1917320814 hasConceptScore W1917320814C54355233 @default.
• W1917320814 hasConceptScore W1917320814C71924100 @default.
• W1917320814 hasConceptScore W1917320814C86803240 @default.
• W1917320814 hasConceptScore W1917320814C87644729 @default.
• W1917320814 hasIssue "5" @default.
• W1917320814 hasLocation W19173208141 @default.
• W1917320814 hasOpenAccess W1917320814 @default.
• W1917320814 hasPrimaryLocation W19173208141 @default.
• W1917320814 hasRelatedWork W1970327593 @default.
• W1917320814 hasRelatedWork W1981271870 @default.
• W1917320814 hasRelatedWork W1988517967 @default.
• W1917320814 hasRelatedWork W2016335393 @default.
• W1917320814 hasRelatedWork W2057739827 @default.
• W1917320814 hasRelatedWork W2070922469 @default.
• W1917320814 hasRelatedWork W2073595570 @default.
• W1917320814 hasRelatedWork W2223919059 @default.
• W1917320814 hasRelatedWork W3165452661 @default.
• W1917320814 hasRelatedWork W4289931431 @default.
• W1917320814 hasVolume "20" @default.
• W1917320814 isParatext "false" @default.
• W1917320814 isRetracted "false" @default.
• W1917320814 magId "1917320814" @default.
• W1917320814 workType "article" @default.