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- W1917382590 endingPage "8103" @default.
- W1917382590 startingPage "8094" @default.
- W1917382590 abstract "Serotonin (5-hydroxytryptamine, 5-HT) modulates the behavior and physiology of both vertebrate and invertebrate animals. Effects of injections of 5-HT and the morphology of the serotonergic system of<i>Aplysia</i> indicate that 5-HT may have a humoral, in addition to a neurotransmitter, role. To study possible humoral roles of 5-HT, we measured 5-HT in the hemolymph. The concentration of 5-HT in the hemolymph was ∼18 nm, a value close to previously reported thresholds for eliciting physiological responses. The concentration of 5-HT in the hemolymph expressed a diurnal rhythm. In addition, electrical stimulation that leads to long-term sensitization significantly increased levels of 5-HT in the hemolymph during training, 1.5 hr after training, and 24 hr after training. Moreover, levels of 5-HT in the hemolymph were significantly correlated with the magnitude of sensitization. The half-life of an increase in 5-HT in the hemolymph was ∼0.5 hr. Therefore, the persistent increase of 5-HT in the hemolymph 24 hr after sensitization training indicates that training caused a long-lasting increase in the release of 5-HT. This long-lasting increase in 5-HT in the hemolymph was blocked by treatment with an inhibitor of protein synthesis during training. Based on the levels of 5-HT in the hemolymph and its regulation by environmental events, we propose that 5-HT has a humoral role in regulation of the behavioral state of <i>Aplysia</i>. In support of this hypothesis, we found that increasing levels of 5-HT in the hemolymph led to significant alterations in feeding behavior. Increasing levels of 5-HT during the daytime when they were normally low increased the latency to assume feeding posture from daytime to nighttime values." @default.
- W1917382590 created "2016-06-24" @default.
- W1917382590 creator A5002612886 @default.
- W1917382590 creator A5084117702 @default.
- W1917382590 creator A5091803592 @default.
- W1917382590 date "1999-09-15" @default.
- W1917382590 modified "2023-10-03" @default.
- W1917382590 title "Levels of Serotonin in the Hemolymph of<i>Aplysia</i>Are Modulated by Light/Dark Cycles and Sensitization Training" @default.
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