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- W1917426361 abstract "The metabolism of a number of water-soluble vitamins by mongoloid and non-mongoloid, all mentally deficient children, has been studied. Relatively little differences in the excretion of thiamine, riboflavin, niacin, N-methylnicotinamide and vitamin C were observed prior to vitamin load tests. Following the load tests no significant difference was observed in the excretion of riboflavin by mongoloids and non-mongoloids and the excretion of thiamine although slightly greater in mongoloids was not marked. The administration of 100 mg of nicotinamide resulted in significantly less excretion of ɴ-methylnicotinamide and creatinine by mongoloids than non-mongoloids. The possibility of a defect in the methylating ability of mongoloids has been suggested. Following the feeding of 5 g of ᴅ ʟ-tryptophan, significant differences in $-methylnicotinamide and creatinine excretion were not observed, but the excretion of xanthurenic acid was lower in mongoloids than non-mongoloids." @default.
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- W1917426361 date "1958-09-01" @default.
- W1917426361 modified "2023-09-27" @default.
- W1917426361 title "Metabolic Studies of Mongoloids" @default.
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- W1917426361 doi "https://doi.org/10.1093/ajcn/6.5.526" @default.
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