Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917451729> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W1917451729 endingPage "71" @default.
- W1917451729 startingPage "1266" @default.
- W1917451729 abstract "A method was developed for continuously exposing tracheal epithelium to measured amounts of carcinogen. Beeswax was the vehicle for sustained release of carcinogen, and tracheas transplanted to s.c. sites were target tissues. In the experiment reported here, transplanted rat tracheas were exposed to a potent carcinogen, 7,12-di-methyl benz(a)anthracene (DMBA). The rate of release of DMBA from the beeswax carrier within the tracheal lumen approached first order when the initial concentration of carcinogen was high (3200 to 325 microng in a 24.45-mg pellet). With lower concentrations, where the carcinogen was dissolved in the beeswax, initial release was rapid, and most of the carcinogen was delivered within 4 weeks. At high DMBA dose levels, the entire tracheal epithelium was uniformly replaced by keratinizing squamous metaplasia after 1 week of exposure, and after 2 months, when from 280 to 910 microng DMBA had been delivered, all transplants had developed invasive squamous carcinomas. Sarcomas also developed in 19% of the transplants. At lower dose levels the epithelial reactions were more varied, and tumor development was more protracted. The lowest DMBA dose presently known to diduce carcinomas in this experimental model is 40 microng, which is in the dose range used for tumor initiation in skin carcinogenesis studies in mice." @default.
- W1917451729 created "2016-06-24" @default.
- W1917451729 creator A5012736997 @default.
- W1917451729 creator A5027196799 @default.
- W1917451729 creator A5046900398 @default.
- W1917451729 creator A5075105459 @default.
- W1917451729 date "1977-05-01" @default.
- W1917451729 modified "2023-09-23" @default.
- W1917451729 title "Quantitative exposure of grafted rat tracheas to 7, 12-dimethylbenz(a)anthracene." @default.
- W1917451729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/404031" @default.
- W1917451729 hasPublicationYear "1977" @default.
- W1917451729 type Work @default.
- W1917451729 sameAs 1917451729 @default.
- W1917451729 citedByCount "13" @default.
- W1917451729 crossrefType "journal-article" @default.
- W1917451729 hasAuthorship W1917451729A5012736997 @default.
- W1917451729 hasAuthorship W1917451729A5027196799 @default.
- W1917451729 hasAuthorship W1917451729A5046900398 @default.
- W1917451729 hasAuthorship W1917451729A5075105459 @default.
- W1917451729 hasConcept C104317684 @default.
- W1917451729 hasConcept C114246631 @default.
- W1917451729 hasConcept C142724271 @default.
- W1917451729 hasConcept C185592680 @default.
- W1917451729 hasConcept C2776260934 @default.
- W1917451729 hasConcept C2778938436 @default.
- W1917451729 hasConcept C2779563022 @default.
- W1917451729 hasConcept C529295009 @default.
- W1917451729 hasConcept C55493867 @default.
- W1917451729 hasConcept C555283112 @default.
- W1917451729 hasConcept C71924100 @default.
- W1917451729 hasConcept C75473681 @default.
- W1917451729 hasConceptScore W1917451729C104317684 @default.
- W1917451729 hasConceptScore W1917451729C114246631 @default.
- W1917451729 hasConceptScore W1917451729C142724271 @default.
- W1917451729 hasConceptScore W1917451729C185592680 @default.
- W1917451729 hasConceptScore W1917451729C2776260934 @default.
- W1917451729 hasConceptScore W1917451729C2778938436 @default.
- W1917451729 hasConceptScore W1917451729C2779563022 @default.
- W1917451729 hasConceptScore W1917451729C529295009 @default.
- W1917451729 hasConceptScore W1917451729C55493867 @default.
- W1917451729 hasConceptScore W1917451729C555283112 @default.
- W1917451729 hasConceptScore W1917451729C71924100 @default.
- W1917451729 hasConceptScore W1917451729C75473681 @default.
- W1917451729 hasIssue "5" @default.
- W1917451729 hasLocation W19174517291 @default.
- W1917451729 hasOpenAccess W1917451729 @default.
- W1917451729 hasPrimaryLocation W19174517291 @default.
- W1917451729 hasRelatedWork W1554537892 @default.
- W1917451729 hasRelatedWork W2033587424 @default.
- W1917451729 hasRelatedWork W2063641666 @default.
- W1917451729 hasRelatedWork W2085441875 @default.
- W1917451729 hasRelatedWork W2092703933 @default.
- W1917451729 hasRelatedWork W2168444622 @default.
- W1917451729 hasRelatedWork W2414492442 @default.
- W1917451729 hasRelatedWork W2460918933 @default.
- W1917451729 hasRelatedWork W2573196299 @default.
- W1917451729 hasRelatedWork W628537020 @default.
- W1917451729 hasVolume "37" @default.
- W1917451729 isParatext "false" @default.
- W1917451729 isRetracted "false" @default.
- W1917451729 magId "1917451729" @default.
- W1917451729 workType "article" @default.