FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917489923> ?p ?o ?g. }

• W1917489923 endingPage "2115" @default.
• W1917489923 startingPage "2109" @default.
• W1917489923 abstract "The activity of pleconaril in cell culture against prototypic enterovirus strains and 215 clinical isolates of the most commonly isolated enterovirus serotypes was examined. The latter viruses were isolated by the Centers for Disease Control and Prevention during the 1970s and 1980s from clinically ill subjects. Pleconaril at a concentration of </=0.03 microM inhibited the replication of 50% of all clinical isolates tested. Ninety percent of the isolates were inhibited at a drug concentration of </=0.18 microM. The most sensitive serotype, echovirus serotype 11, was also the most prevalent enterovirus in the United States from 1970 to 1983. Pleconaril was further tested for oral activity in three animal models of lethal enterovirus infection: coxsackievirus serotype A9 infection in suckling mice, coxsackievirus serotype A21 strain Kenny infection in weanling mice, and coxsackievirus serotype B3 strain M infection in adult mice. Treatment with pleconaril increased the survival rate in all three models for both prophylactic and therapeutic dosing regimens. Moreover, pleconaril dramatically reduced virus levels in target tissues of coxsackievirus serotype B3 strain M-infected animals. Pleconaril represents a promising new drug candidate for potential use in the treatment of human enteroviral infections." @default.
• W1917489923 created "2016-06-24" @default.
• W1917489923 creator A5018177093 @default.
• W1917489923 creator A5028212364 @default.
• W1917489923 creator A5041876321 @default.
• W1917489923 creator A5058525714 @default.
• W1917489923 date "1999-09-01" @default.
• W1917489923 modified "2023-10-01" @default.
• W1917489923 title "Activity of Pleconaril against Enteroviruses" @default.
• W1917489923 cites W1032171471 @default.
• W1917489923 cites W1830634530 @default.
• W1917489923 cites W1964268144 @default.
• W1917489923 cites W1973127311 @default.
• W1917489923 cites W1981522944 @default.
• W1917489923 cites W1985795782 @default.
• W1917489923 cites W1986593544 @default.
• W1917489923 cites W2014318405 @default.
• W1917489923 cites W2018762523 @default.
• W1917489923 cites W2028322391 @default.
• W1917489923 cites W2045610628 @default.
• W1917489923 cites W2046207265 @default.
• W1917489923 cites W2046253838 @default.
• W1917489923 cites W2048178108 @default.
• W1917489923 cites W2048271547 @default.
• W1917489923 cites W2055299349 @default.
• W1917489923 cites W2065264417 @default.
• W1917489923 cites W2067650781 @default.
• W1917489923 cites W2068668309 @default.
• W1917489923 cites W2074858827 @default.
• W1917489923 cites W2078279000 @default.
• W1917489923 cites W2082493192 @default.
• W1917489923 cites W2084352383 @default.
• W1917489923 cites W2088534734 @default.
• W1917489923 cites W2094664206 @default.
• W1917489923 cites W2110014485 @default.
• W1917489923 cites W2114918609 @default.
• W1917489923 cites W2118444989 @default.
• W1917489923 cites W2142764722 @default.
• W1917489923 cites W2154306061 @default.
• W1917489923 cites W2161455368 @default.
• W1917489923 cites W2170265040 @default.
• W1917489923 cites W2239664718 @default.
• W1917489923 cites W2327119157 @default.
• W1917489923 cites W2337133922 @default.
• W1917489923 cites W2479054800 @default.
• W1917489923 cites W2951411853 @default.
• W1917489923 cites W4211057466 @default.
• W1917489923 cites W4234094424 @default.
• W1917489923 cites W587298658 @default.
• W1917489923 cites W2062897392 @default.
• W1917489923 doi "https://doi.org/10.1128/aac.43.9.2109" @default.
• W1917489923 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/89431" @default.
• W1917489923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10471549" @default.
• W1917489923 hasPublicationYear "1999" @default.
• W1917489923 type Work @default.
• W1917489923 sameAs 1917489923 @default.
• W1917489923 citedByCount "308" @default.
• W1917489923 countsByYear W19174899232012 @default.
• W1917489923 countsByYear W19174899232013 @default.
• W1917489923 countsByYear W19174899232014 @default.
• W1917489923 countsByYear W19174899232015 @default.
• W1917489923 countsByYear W19174899232016 @default.
• W1917489923 countsByYear W19174899232017 @default.
• W1917489923 countsByYear W19174899232018 @default.
• W1917489923 countsByYear W19174899232019 @default.
• W1917489923 countsByYear W19174899232020 @default.
• W1917489923 countsByYear W19174899232021 @default.
• W1917489923 countsByYear W19174899232022 @default.
• W1917489923 countsByYear W19174899232023 @default.
• W1917489923 crossrefType "journal-article" @default.
• W1917489923 hasAuthorship W1917489923A5018177093 @default.
• W1917489923 hasAuthorship W1917489923A5028212364 @default.
• W1917489923 hasAuthorship W1917489923A5041876321 @default.
• W1917489923 hasAuthorship W1917489923A5058525714 @default.
• W1917489923 hasBestOaLocation W19174899231 @default.
• W1917489923 hasConcept C10389963 @default.
• W1917489923 hasConcept C159047783 @default.
• W1917489923 hasConcept C2522874641 @default.
• W1917489923 hasConcept C2777888124 @default.
• W1917489923 hasConcept C2778819740 @default.
• W1917489923 hasConcept C2779120600 @default.
• W1917489923 hasConcept C86803240 @default.
• W1917489923 hasConcept C89423630 @default.
• W1917489923 hasConceptScore W1917489923C10389963 @default.
• W1917489923 hasConceptScore W1917489923C159047783 @default.
• W1917489923 hasConceptScore W1917489923C2522874641 @default.
• W1917489923 hasConceptScore W1917489923C2777888124 @default.
• W1917489923 hasConceptScore W1917489923C2778819740 @default.
• W1917489923 hasConceptScore W1917489923C2779120600 @default.
• W1917489923 hasConceptScore W1917489923C86803240 @default.
• W1917489923 hasConceptScore W1917489923C89423630 @default.
• W1917489923 hasIssue "9" @default.
• W1917489923 hasLocation W19174899231 @default.
• W1917489923 hasLocation W19174899232 @default.
• W1917489923 hasLocation W19174899233 @default.
• W1917489923 hasLocation W19174899234 @default.
• W1917489923 hasOpenAccess W1917489923 @default.
• W1917489923 hasPrimaryLocation W19174899231 @default.

• next