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• W1917498192 startingPage "456" @default.
• W1917498192 abstract "<ns4:p>Suvorexant is a novel dual orexin receptor antagonist (DORA) newly introduced in the U.S. as a hypnotic, but no claim of superiority over other hypnotics has been offered. The manufacturer argued that the 5 and 10 mg starting doses recommended by the FDA might be ineffective. The manufacturer's main Phase III trials had not even included the 10 mg dosage, and the 5 mg dosage had not been tested at all in registered clinical trials at the time of approval. Popular alternative hypnotics may be similarly ineffective, since the FDA has also reduced the recommended doses for zolpidem and eszopiclone. The not to exceed suvorexant dosage of 20 mg does slightly increase sleep. Because of slow absorption, suvorexant has little effect on latency to sleep onset but some small effect in suppressing wakening after sleep onset and in improving sleep efficiency. The FDA would not approve the manufacturer's preferred 40 mg suvorexant dosage, because of concern with daytime somnolence, driving impairment, and possible narcolepsy-like symptoms. In its immediate benefits-to-risks ratio, suvorexant is unlikely to prove superior to currently available hypnotics—possibly worse—so there is little reason to prefer over the alternatives this likely more expensive hypnotic less-tested in practice. Associations are being increasingly documented relating hypnotic usage with incident cancer, with dementia risks, and with premature death. There is some basis to speculate that suvorexant might be safer than alternative hypnotics in terms of cancer, dementia, infections, and mortality. These safety considerations will remain unproven speculations unless adequate long-term trials can be done that demonstrate suvorexant advantages.</ns4:p>" @default.
• W1917498192 created "2016-06-24" @default.
• W1917498192 creator A5012766008 @default.
• W1917498192 date "2015-08-03" @default.
• W1917498192 modified "2023-10-01" @default.
• W1917498192 title "Is suvorexant a better choice than alternative hypnotics?" @default.
• W1917498192 cites W147714449 @default.
• W1917498192 cites W1493631176 @default.
• W1917498192 cites W1519232679 @default.
• W1917498192 cites W1533063439 @default.
• W1917498192 cites W1575624911 @default.
• W1917498192 cites W1616724735 @default.
• W1917498192 cites W1627229807 @default.
• W1917498192 cites W1659903544 @default.
• W1917498192 cites W1791264103 @default.
• W1917498192 cites W1945221175 @default.
• W1917498192 cites W1952543825 @default.
• W1917498192 cites W1970323512 @default.
• W1917498192 cites W1971865108 @default.
• W1917498192 cites W1975850270 @default.
• W1917498192 cites W1975898841 @default.
• W1917498192 cites W1976591322 @default.
• W1917498192 cites W1978925858 @default.
• W1917498192 cites W1979613446 @default.
• W1917498192 cites W1983298714 @default.
• W1917498192 cites W1984231771 @default.
• W1917498192 cites W1988065740 @default.
• W1917498192 cites W1994089207 @default.
• W1917498192 cites W1996774946 @default.
• W1917498192 cites W2000736071 @default.
• W1917498192 cites W2002669039 @default.
• W1917498192 cites W2002761901 @default.
• W1917498192 cites W2003441551 @default.
• W1917498192 cites W2006612838 @default.
• W1917498192 cites W2010320895 @default.
• W1917498192 cites W2011864278 @default.
• W1917498192 cites W2012118094 @default.
• W1917498192 cites W2013333500 @default.
• W1917498192 cites W2013930533 @default.
• W1917498192 cites W2014163534 @default.
• W1917498192 cites W2014437142 @default.
• W1917498192 cites W2015603515 @default.
• W1917498192 cites W2017424329 @default.
• W1917498192 cites W2018673150 @default.
• W1917498192 cites W2022277372 @default.
• W1917498192 cites W2023243110 @default.
• W1917498192 cites W2023418693 @default.
• W1917498192 cites W2024787431 @default.
• W1917498192 cites W2025559656 @default.
• W1917498192 cites W2025862036 @default.
• W1917498192 cites W2026937220 @default.
• W1917498192 cites W2028026454 @default.
• W1917498192 cites W2033060781 @default.
• W1917498192 cites W2034625499 @default.
• W1917498192 cites W2036163096 @default.
• W1917498192 cites W2039647336 @default.
• W1917498192 cites W2044712116 @default.
• W1917498192 cites W2044985256 @default.
• W1917498192 cites W2045069726 @default.
• W1917498192 cites W2053667928 @default.
• W1917498192 cites W2059078922 @default.
• W1917498192 cites W2061497773 @default.
• W1917498192 cites W2062124103 @default.
• W1917498192 cites W2064290559 @default.
• W1917498192 cites W2074520087 @default.
• W1917498192 cites W2075792413 @default.
• W1917498192 cites W2077895426 @default.
• W1917498192 cites W2078639263 @default.
• W1917498192 cites W2080809536 @default.
• W1917498192 cites W2082748383 @default.
• W1917498192 cites W2085712847 @default.
• W1917498192 cites W2091155562 @default.
• W1917498192 cites W2091908519 @default.
• W1917498192 cites W2093669603 @default.
• W1917498192 cites W2107564914 @default.
• W1917498192 cites W2108212934 @default.
• W1917498192 cites W2109170767 @default.
• W1917498192 cites W2110187221 @default.
• W1917498192 cites W2112321133 @default.
• W1917498192 cites W2113295696 @default.
• W1917498192 cites W2113680767 @default.
• W1917498192 cites W2113732004 @default.
• W1917498192 cites W2115866147 @default.
• W1917498192 cites W2116618605 @default.
• W1917498192 cites W2118026523 @default.
• W1917498192 cites W2118077185 @default.
• W1917498192 cites W2119998765 @default.
• W1917498192 cites W2125811519 @default.
• W1917498192 cites W2126523529 @default.
• W1917498192 cites W2130384863 @default.
• W1917498192 cites W2135074291 @default.
• W1917498192 cites W2137881648 @default.
• W1917498192 cites W2138006666 @default.
• W1917498192 cites W2139341657 @default.
• W1917498192 cites W2145285461 @default.
• W1917498192 cites W2151482188 @default.
• W1917498192 cites W2159480936 @default.
• W1917498192 cites W2161393466 @default.

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