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• W1917503746 abstract "Voltage-gated proton channels are strongly inhibited by Zn2+, which binds to His residues. However, in a molecular model, the two externally accessible His are too far apart to coordinate Zn2+. We hypothesize that high-affinity Zn2+ binding occurs at the dimer interface between pairs of His residues from both monomers. Consistent with this idea, Zn2+ effects were weaker in monomeric channels. Mutation of His193 and His140 in various combinations and in tandem dimers revealed that channel opening was slowed by Zn2+ only when at least one His was present in each monomer, suggesting that in wild-type (WT) HV1, Zn2+ binding between His of both monomers inhibits channel opening. In addition, monomeric channels opened exponentially, and dimeric channels opened sigmoidally. Monomeric channel gating had weaker temperature dependence than dimeric channels. Finally, monomeric channels opened 6.6 times faster than dimeric channels. Together, these observations suggest that in the proton channel dimer, the two monomers are closely apposed and interact during a cooperative gating process. Zn2+ appears to slow opening by preventing movement of the monomers relative to each other that is prerequisite to opening. These data also suggest that the association of the monomers is tenuous and allows substantial freedom of movement. The data support the idea that native proton channels are dimeric. Finally, the idea that monomer–dimer interconversion occurs during activation of phagocytes appears to be ruled out." @default.
• W1917503746 created "2016-06-24" @default.
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• W1917503746 date "2010-04-30" @default.
• W1917503746 modified "2023-10-14" @default.
• W1917503746 title "Zinc inhibition of monomeric and dimeric proton channels suggests cooperative gating" @default.
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• W1917503746 doi "https://doi.org/10.1113/jphysiol.2010.188318" @default.
• W1917503746 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2876801" @default.
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