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• W1917558595 endingPage "1947" @default.
• W1917558595 startingPage "1933" @default.
• W1917558595 abstract "Abstract Data from 1238 fishes from 19 sturgeon species and 1 paddlefish were used to analyze heteroplasmy in sturgeon. Lengths of central repeat units ranged from 74 to 83 bp among sturgeon species. No repeat sequence was found in the paddlefish, Polyodon spathula. A general feature of the repeat units was the presence of termination associated sequence (TAS) motifs. About 50% of 138 interspecific mutations observed among the D-loop sequences are located 10 bp down- and upstream from these TAS motifs. Interestingly, most homoplasmic species showed deletions upstream to the TAS motifs, whereas deletions downstream to the TAS motifs observed in two species do not seem to preclude heteroplasmy. Calculations of secondary structures and thermal stabilities of repeat units showed ΔG values for all heteroplasmic species to be &lt;-8 and for most homoplasmic species ΔG value to be &gt;-8. Most heteroplasmic fishes had two and/or three repeat units. No homoplasmic sturgeon with &gt;2 repeat units were observed. Molecular phylogeny based on the entire cytochrome b showed that heteroplasmy probably resulted from a single evolutionary event. Our data demonstrate that heteroplasmy is present in most sturgeon species and suggest that the thermal stability of the secondary structure of the repeat unit in combination with mutations downstream of the TAS sequences influences heteroplasmy." @default.
• W1917558595 created "2016-06-24" @default.
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• W1917558595 date "2000-12-01" @default.
• W1917558595 modified "2023-10-18" @default.
• W1917558595 title "Heteroplasmy in the mtDNA Control Region of Sturgeon (<i>Acipenser</i>, <i>Huso</i> and <i>Scaphirhynchus</i>)" @default.
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• W1917558595 doi "https://doi.org/10.1093/genetics/156.4.1933" @default.
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