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- W1917672468 endingPage "161" @default.
- W1917672468 startingPage "161" @default.
- W1917672468 abstract "The tumor biology targeted therapies have improved outcomes in colorectal cancer (CRC). The epidermal growth factor receptor (EGFR) inhibitors represent one of these successful strategies. EGFR is frequently overexpressed in CRCs and associated with a malignant phenotype. Two EGFR inhibitors have shown efficacy in metastatic CRC, cetuximab and panitumumab. Cetuximab is a human-mouse chimeric monoclonal antibody that binds to the extracellular domain of the EGF-receptor. Similarly, panitumumab is a fully humanized monoclonal IgG(2) antibody, directed against EGFR. Being fully humanized, panitumumab does not contain mouse protein reducing the risk of hypersensitivity. In a pivotal clinical trial, panitumumab was well tolerated and effective, demonstrating an objective response rate of 10% vs best supportive care (ORR = 0%; P < 0.0001). Panitumumab was approved for the treatment of mCRC by the FDA in 2006. Studies combining panitumumab with cytotoxic chemotherapy and other targeted therapies have been completed while others are ongoing to further evaluate the clinical utility of this agent. Recently it has been demonstrated that mutations in KRAS predict the efficacy of panitumumab and cetuximab, limiting their use to CRC patients with wild-type KRAS, and moving the clinical field towards personalized cancer care." @default.
- W1917672468 created "2016-06-24" @default.
- W1917672468 creator A5064343766 @default.
- W1917672468 creator A5069214655 @default.
- W1917672468 date "2009-06-01" @default.
- W1917672468 modified "2023-09-27" @default.
- W1917672468 title "Targeting colorectal cancer with anti-epidermal growth factor receptor antibodies: focus on panitumumab" @default.
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- W1917672468 doi "https://doi.org/10.2147/ott.s3849" @default.
- W1917672468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2886332" @default.
- W1917672468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20616903" @default.
- W1917672468 hasPublicationYear "2009" @default.
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