Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917776164> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W1917776164 endingPage "24" @default.
- W1917776164 startingPage "315" @default.
- W1917776164 abstract "1. Compound #715 was highly effective in well-tolerated (doses by the drug diet method against natural pinworm infections of mice and rats and against experimental infections of Strongyloides ratti in rats, hut was less effective against these infections when given by gavage. In tests by the (drug diet method for 6 days against Syphacia obvelata and Aspiculuris tetraptera of mice the respective ED50's were approximately 2.75 and 9.6 mgm. kgm./day. Thus #715 was approximately 40 and 5 times, respectively, as active as gentian violet against the two species of worms. The drug compared favorably with gentian violet in the other tests of ant helmintic action.2. Rodent acute oral toxicity studies resulted in LD50's of 7.9 mgm. kgm. for mice and 161 mgm. kgm. for rats.3. Rodent chronic oral toxicity tests over a 4-week periodi showed mice tolerate a maximum of 18 mgm./kgm. day by the drug diet method (0.0125 per cent diet concentration) and rats tolerate a maximum of 52 mgm. kgm. day (0.0625 per cent. concentration). However, the rats receiving this dose gained only ⅓ as much weight as parallel controls.4. Dogs tolerated 10-40 mgm./kgm. twice daily, 5 days per week for periods of 5-7 weeks without evidence of toxicity; doses of 40-80 mgm. kgm. twice daily for similar periods were associated with weight loss, vomiting, diarrhea and an occasional decrease in hemoglobin and numbers of erythrocytes, although the bone marrow apparently remained unaffected.5. Pathologically, #715 administration was associated with mild to moderate irritation of the small intestine and mild degrees of liver and kidney damage; these signs occurred primarily at the higher chronic dose levels in both dogs and rodents and appeared to be reversible. Two rats on chronic administration at grossly toxic levels showed severe bone marrow hypoplasia. However, no evidence of this effect was detected in numerous other rats on lower dose levels or in dogs.6. The possible usefulness of #15 in human oxyuriasis is considered." @default.
- W1917776164 created "2016-06-24" @default.
- W1917776164 creator A5032907078 @default.
- W1917776164 creator A5053802690 @default.
- W1917776164 creator A5063469472 @default.
- W1917776164 creator A5073048912 @default.
- W1917776164 creator A5077506814 @default.
- W1917776164 date "1953-03-01" @default.
- W1917776164 modified "2023-10-16" @default.
- W1917776164 title "Antioxyurid activity, toxicology and pathology in laboratory animals of a cyanine dye [6-dimethylamino-2[2-(2, 5-dimethyl-1-phenyl-3-pyrryl)vinyl]-1-methyl-quinolinium chloride." @default.
- W1917776164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13035670" @default.
- W1917776164 hasPublicationYear "1953" @default.
- W1917776164 type Work @default.
- W1917776164 sameAs 1917776164 @default.
- W1917776164 citedByCount "3" @default.
- W1917776164 crossrefType "journal-article" @default.
- W1917776164 hasAuthorship W1917776164A5032907078 @default.
- W1917776164 hasAuthorship W1917776164A5053802690 @default.
- W1917776164 hasAuthorship W1917776164A5063469472 @default.
- W1917776164 hasAuthorship W1917776164A5073048912 @default.
- W1917776164 hasAuthorship W1917776164A5077506814 @default.
- W1917776164 hasConcept C126322002 @default.
- W1917776164 hasConcept C147583825 @default.
- W1917776164 hasConcept C170493617 @default.
- W1917776164 hasConcept C185592680 @default.
- W1917776164 hasConcept C2780035454 @default.
- W1917776164 hasConcept C2780852908 @default.
- W1917776164 hasConcept C29730261 @default.
- W1917776164 hasConcept C33070731 @default.
- W1917776164 hasConcept C42407357 @default.
- W1917776164 hasConcept C42533223 @default.
- W1917776164 hasConcept C71924100 @default.
- W1917776164 hasConcept C86803240 @default.
- W1917776164 hasConcept C98274493 @default.
- W1917776164 hasConceptScore W1917776164C126322002 @default.
- W1917776164 hasConceptScore W1917776164C147583825 @default.
- W1917776164 hasConceptScore W1917776164C170493617 @default.
- W1917776164 hasConceptScore W1917776164C185592680 @default.
- W1917776164 hasConceptScore W1917776164C2780035454 @default.
- W1917776164 hasConceptScore W1917776164C2780852908 @default.
- W1917776164 hasConceptScore W1917776164C29730261 @default.
- W1917776164 hasConceptScore W1917776164C33070731 @default.
- W1917776164 hasConceptScore W1917776164C42407357 @default.
- W1917776164 hasConceptScore W1917776164C42533223 @default.
- W1917776164 hasConceptScore W1917776164C71924100 @default.
- W1917776164 hasConceptScore W1917776164C86803240 @default.
- W1917776164 hasConceptScore W1917776164C98274493 @default.
- W1917776164 hasIssue "3" @default.
- W1917776164 hasLocation W19177761641 @default.
- W1917776164 hasOpenAccess W1917776164 @default.
- W1917776164 hasPrimaryLocation W19177761641 @default.
- W1917776164 hasRelatedWork W1799442 @default.
- W1917776164 hasRelatedWork W18510784 @default.
- W1917776164 hasRelatedWork W2037491965 @default.
- W1917776164 hasRelatedWork W2064583158 @default.
- W1917776164 hasRelatedWork W206939751 @default.
- W1917776164 hasRelatedWork W2170381017 @default.
- W1917776164 hasRelatedWork W2318295970 @default.
- W1917776164 hasRelatedWork W2808801443 @default.
- W1917776164 hasRelatedWork W2899084033 @default.
- W1917776164 hasRelatedWork W813993346 @default.
- W1917776164 hasVolume "107" @default.
- W1917776164 isParatext "false" @default.
- W1917776164 isRetracted "false" @default.
- W1917776164 magId "1917776164" @default.
- W1917776164 workType "article" @default.