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• W1917793406 abstract "Abstract Background and Aim Although several meta‐analyses suggested that sequential therapy ( SQT ) is superior to standard triple therapy ( STT ) for the eradication of H elicobacter pylori , these results were mainly based on the studies from I taly. The aim of this study was to assess the efficacy of 10‐day SQT for H . pylori infection compared with STT in Asian adults. Methods We performed an electronic search of the Cochrane Library, Medline, and E mbase up to A pril 21, 2013, with no language restrictions. Randomized controlled trials comparing 10‐day SQT with STT for H . pylori eradication in Asian adults were included in this analysis. The primary outcome measures were the risk ratios ( RRs ) for successful eradication of H . pylori based on intention to treat comparing SQT with STT . The secondary outcome measures were the RRs for side effects. Results Seventeen randomized controlled trials with a total of 3419 participants (1591 for SQT and 1828 for STT ) met the inclusion criteria. The eradication rate was 81.8% (95% CI : 78.9−84.6) for SQT and 74.3% (95% CI : 69.6−78.8) for SST , respectively. The pooled RR was 1.10 (95% CI : 1.04−1.16, P = 0.0005), which demonstrated significant superiority of SQT over STT , and the number needed to treat was 14 (95% CI : 9–29). There were no significant differences between SQT and STT in the risk of side effects (the pooled RR : 0.98, 95% CI : 0.87−1.10, P = 0.73). Conclusion Ten‐day SQT appears to be superior to STT for H . pylori eradication in Asian adults. However, the pooled efficacy is lower than results from earlier European studies." @default.
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• W1917793406 date "2013-11-22" @default.
• W1917793406 modified "2023-10-03" @default.
• W1917793406 title "Meta-analysis: Is sequential therapy superior to standard triple therapy for <i>Helicobacter pylori</i> infection in Asian adults?" @default.
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• W1917793406 doi "https://doi.org/10.1111/jgh.12397" @default.
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