Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917940007> ?p ?o ?g. }
- W1917940007 endingPage "2690" @default.
- W1917940007 startingPage "2680" @default.
- W1917940007 abstract "To characterize the unique qualities of proteins associated with circulating subcellular material in systemic lupus erythematosus (SLE) patients compared with healthy controls and patients with other chronic autoimmune diseases.Using differential centrifugation and high-sensitivity nano-liquid chromatography tandem mass spectrometry, we systematically profiled proteins of microparticles (MPs) from SLE patients (n=12), systemic sclerosis (SSc) patients (n=6), and rheumatoid arthritis (RA) patients (n=6), as well as healthy controls (n=12).We identified 531 unique proteins and showed that the differences between healthy controls and patients with SLE with regard to the abundance of 248 proteins were highly statistically significant. Almost half of the proteins that were increased by >2-fold were complement proteins and Ig (increased by 100-4,000 times). MP Ig and complement loads also distinguished SLE from RA and SSc and correlated strongly with clinical SLE severity. Subsets of microtubule proteins, fibronectin, 14-3-3η, and desmosomal proteins as well as ficolin 2 and galectin 3 binding protein were also highly increased. In SLE MPs, levels of cytoskeletal, mitochondrial, and organelle proteins, including lysosome-associated membrane protein 1 and transforming growth factor β1, were decreased.The data show that SLE patients have increased numbers of MPs that are heavily tagged for removal and fewer MPs with normal protein composition. SLE MPs are unique and specific proteins that represent novel leads for our understanding of SLE and for the development of new treatments of the disease." @default.
- W1917940007 created "2016-06-24" @default.
- W1917940007 creator A5013218014 @default.
- W1917940007 creator A5014554542 @default.
- W1917940007 creator A5033697331 @default.
- W1917940007 creator A5053356441 @default.
- W1917940007 creator A5071450479 @default.
- W1917940007 creator A5084601620 @default.
- W1917940007 creator A5086180632 @default.
- W1917940007 date "2013-09-24" @default.
- W1917940007 modified "2023-10-07" @default.
- W1917940007 title "Unique protein signature of circulating microparticles in systemic lupus erythematosus" @default.
- W1917940007 cites W1547996487 @default.
- W1917940007 cites W1549415496 @default.
- W1917940007 cites W1567114372 @default.
- W1917940007 cites W1797148726 @default.
- W1917940007 cites W1964097304 @default.
- W1917940007 cites W1966830640 @default.
- W1917940007 cites W1973431560 @default.
- W1917940007 cites W1980174384 @default.
- W1917940007 cites W2002310936 @default.
- W1917940007 cites W2010242790 @default.
- W1917940007 cites W2011617127 @default.
- W1917940007 cites W2018153809 @default.
- W1917940007 cites W2024374472 @default.
- W1917940007 cites W2028921539 @default.
- W1917940007 cites W2036321220 @default.
- W1917940007 cites W2044638539 @default.
- W1917940007 cites W2053776269 @default.
- W1917940007 cites W2058753589 @default.
- W1917940007 cites W2064919242 @default.
- W1917940007 cites W2064999867 @default.
- W1917940007 cites W2067022007 @default.
- W1917940007 cites W2067217824 @default.
- W1917940007 cites W2070527591 @default.
- W1917940007 cites W2078609262 @default.
- W1917940007 cites W2080752012 @default.
- W1917940007 cites W2082969962 @default.
- W1917940007 cites W2086779671 @default.
- W1917940007 cites W2086928171 @default.
- W1917940007 cites W2089943045 @default.
- W1917940007 cites W2093458935 @default.
- W1917940007 cites W2095537212 @default.
- W1917940007 cites W2106273198 @default.
- W1917940007 cites W2109913264 @default.
- W1917940007 cites W2111019629 @default.
- W1917940007 cites W2113269521 @default.
- W1917940007 cites W2124105964 @default.
- W1917940007 cites W2125358464 @default.
- W1917940007 cites W2127321441 @default.
- W1917940007 cites W2139406636 @default.
- W1917940007 cites W2149295409 @default.
- W1917940007 cites W2152331121 @default.
- W1917940007 cites W2152348310 @default.
- W1917940007 cites W2152891840 @default.
- W1917940007 cites W2155323332 @default.
- W1917940007 cites W2162966650 @default.
- W1917940007 cites W2316480313 @default.
- W1917940007 cites W2324322428 @default.
- W1917940007 cites W4233334497 @default.
- W1917940007 cites W4240072870 @default.
- W1917940007 cites W4323241890 @default.
- W1917940007 doi "https://doi.org/10.1002/art.38065" @default.
- W1917940007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23817959" @default.
- W1917940007 hasPublicationYear "2013" @default.
- W1917940007 type Work @default.
- W1917940007 sameAs 1917940007 @default.
- W1917940007 citedByCount "54" @default.
- W1917940007 countsByYear W19179400072014 @default.
- W1917940007 countsByYear W19179400072015 @default.
- W1917940007 countsByYear W19179400072016 @default.
- W1917940007 countsByYear W19179400072017 @default.
- W1917940007 countsByYear W19179400072018 @default.
- W1917940007 countsByYear W19179400072019 @default.
- W1917940007 countsByYear W19179400072020 @default.
- W1917940007 countsByYear W19179400072021 @default.
- W1917940007 countsByYear W19179400072022 @default.
- W1917940007 countsByYear W19179400072023 @default.
- W1917940007 crossrefType "journal-article" @default.
- W1917940007 hasAuthorship W1917940007A5013218014 @default.
- W1917940007 hasAuthorship W1917940007A5014554542 @default.
- W1917940007 hasAuthorship W1917940007A5033697331 @default.
- W1917940007 hasAuthorship W1917940007A5053356441 @default.
- W1917940007 hasAuthorship W1917940007A5071450479 @default.
- W1917940007 hasAuthorship W1917940007A5084601620 @default.
- W1917940007 hasAuthorship W1917940007A5086180632 @default.
- W1917940007 hasConcept C108625454 @default.
- W1917940007 hasConcept C111684460 @default.
- W1917940007 hasConcept C126322002 @default.
- W1917940007 hasConcept C132946820 @default.
- W1917940007 hasConcept C146543888 @default.
- W1917940007 hasConcept C153911025 @default.
- W1917940007 hasConcept C159654299 @default.
- W1917940007 hasConcept C203014093 @default.
- W1917940007 hasConcept C2775915377 @default.
- W1917940007 hasConcept C2777575956 @default.
- W1917940007 hasConcept C71924100 @default.
- W1917940007 hasConcept C86803240 @default.