FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1917966482> ?p ?o ?g. }

• W1917966482 endingPage "387" @default.
• W1917966482 startingPage "381" @default.
• W1917966482 abstract "Acyl coenzyme A:cholesterol acyl transferase and/or cholesterol esterase may regulate the esterification and absorption of exogenous cholesterol. To assess this, mucosal acyl coenzyme A:cholesterol acyl transferase activity was inhibited selectively with three different drugs [Sandoz #58-035, inhibitor 1; Lederle inhibitor 2 and inhibitor 3] and the effect upon the absorption of a [4-14C]cholesterol meal was studied in the lymph fistula rat. Compared to control rats, ACAT activity measured in mucosal homogenates from the drug-treated rats was reduced 80-90%, 40%, and 30%, respectively, during the predicted time-frame for maximum mucosal esterification of cholesterol (i.e., after cholesterol is fed and before it appears in lymph). In contrast, [14C]cholesterol absorption in the drug-treated animals was unchanged from controls [5.7 +/- 1.2 (inhibitor 1) vs. 5.4 +/- 1.6 mumol/6 hr (control); 6.1 +/- 2.1 (inhibitor 2) and 5.2 +/- 1.5 (inhibitor 3) vs. 4.1 +/- 1.3 mumol/6 hr (control)]. Of the absorbed [14C]cholesterol, approximately 75% was esterified in all groups. Cholesterol esterase activity measured in the drug-treated rats was unchanged compared to controls nor did the drugs inhibit this enzyme in vitro. Under the conditions of this study, drugs causing substantial inhibition of acyl coenzyme A:cholesterol acyl transferase activity had no effect on the absorption of exogenous cholesterol." @default.
• W1917966482 created "2016-06-24" @default.
• W1917966482 creator A5007456324 @default.
• W1917966482 creator A5011535435 @default.
• W1917966482 creator A5036024962 @default.
• W1917966482 date "1987-04-01" @default.
• W1917966482 modified "2023-09-30" @default.
• W1917966482 title "Normal cholesterol absorption in rats deficient in intestinal acyl coenzyme A:cholesterol acyltransferase activity" @default.
• W1917966482 cites W1514308108 @default.
• W1917966482 cites W1519166819 @default.
• W1917966482 cites W1966672139 @default.
• W1917966482 cites W2010454667 @default.
• W1917966482 cites W2013913080 @default.
• W1917966482 cites W2036050517 @default.
• W1917966482 cites W2044893835 @default.
• W1917966482 cites W2046006081 @default.
• W1917966482 cites W2095614538 @default.
• W1917966482 cites W2099938055 @default.
• W1917966482 cites W2168526937 @default.
• W1917966482 cites W2173237738 @default.
• W1917966482 cites W21836373 @default.
• W1917966482 cites W2186320764 @default.
• W1917966482 cites W2187495493 @default.
• W1917966482 cites W2189179707 @default.
• W1917966482 cites W2292923616 @default.
• W1917966482 cites W2317339985 @default.
• W1917966482 cites W2326496170 @default.
• W1917966482 cites W2343672922 @default.
• W1917966482 cites W2397229039 @default.
• W1917966482 cites W2415042201 @default.
• W1917966482 cites W2415979451 @default.
• W1917966482 cites W2417065058 @default.
• W1917966482 doi "https://doi.org/10.1016/s0022-2275(20)38691-0" @default.
• W1917966482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3585173" @default.
• W1917966482 hasPublicationYear "1987" @default.
• W1917966482 type Work @default.
• W1917966482 sameAs 1917966482 @default.
• W1917966482 citedByCount "32" @default.
• W1917966482 countsByYear W19179664822012 @default.
• W1917966482 countsByYear W19179664822015 @default.
• W1917966482 countsByYear W19179664822016 @default.
• W1917966482 crossrefType "journal-article" @default.
• W1917966482 hasAuthorship W1917966482A5007456324 @default.
• W1917966482 hasAuthorship W1917966482A5011535435 @default.
• W1917966482 hasAuthorship W1917966482A5036024962 @default.
• W1917966482 hasBestOaLocation W19179664821 @default.
• W1917966482 hasConcept C110459506 @default.
• W1917966482 hasConcept C125287762 @default.
• W1917966482 hasConcept C126322002 @default.
• W1917966482 hasConcept C134018914 @default.
• W1917966482 hasConcept C134651460 @default.
• W1917966482 hasConcept C159985019 @default.
• W1917966482 hasConcept C181199279 @default.
• W1917966482 hasConcept C185592680 @default.
• W1917966482 hasConcept C192562407 @default.
• W1917966482 hasConcept C2778163477 @default.
• W1917966482 hasConcept C2779123261 @default.
• W1917966482 hasConcept C2779685201 @default.
• W1917966482 hasConcept C2780072125 @default.
• W1917966482 hasConcept C2910079589 @default.
• W1917966482 hasConcept C37002583 @default.
• W1917966482 hasConcept C553450214 @default.
• W1917966482 hasConcept C55493867 @default.
• W1917966482 hasConcept C71924100 @default.
• W1917966482 hasConcept C86803240 @default.
• W1917966482 hasConceptScore W1917966482C110459506 @default.
• W1917966482 hasConceptScore W1917966482C125287762 @default.
• W1917966482 hasConceptScore W1917966482C126322002 @default.
• W1917966482 hasConceptScore W1917966482C134018914 @default.
• W1917966482 hasConceptScore W1917966482C134651460 @default.
• W1917966482 hasConceptScore W1917966482C159985019 @default.
• W1917966482 hasConceptScore W1917966482C181199279 @default.
• W1917966482 hasConceptScore W1917966482C185592680 @default.
• W1917966482 hasConceptScore W1917966482C192562407 @default.
• W1917966482 hasConceptScore W1917966482C2778163477 @default.
• W1917966482 hasConceptScore W1917966482C2779123261 @default.
• W1917966482 hasConceptScore W1917966482C2779685201 @default.
• W1917966482 hasConceptScore W1917966482C2780072125 @default.
• W1917966482 hasConceptScore W1917966482C2910079589 @default.
• W1917966482 hasConceptScore W1917966482C37002583 @default.
• W1917966482 hasConceptScore W1917966482C553450214 @default.
• W1917966482 hasConceptScore W1917966482C55493867 @default.
• W1917966482 hasConceptScore W1917966482C71924100 @default.
• W1917966482 hasConceptScore W1917966482C86803240 @default.
• W1917966482 hasIssue "4" @default.
• W1917966482 hasLocation W19179664821 @default.
• W1917966482 hasOpenAccess W1917966482 @default.
• W1917966482 hasPrimaryLocation W19179664821 @default.
• W1917966482 hasRelatedWork W1606057223 @default.
• W1917966482 hasRelatedWork W1966672139 @default.
• W1917966482 hasRelatedWork W1966834268 @default.
• W1917966482 hasRelatedWork W1967586555 @default.
• W1917966482 hasRelatedWork W2008892820 @default.
• W1917966482 hasRelatedWork W2022923134 @default.
• W1917966482 hasRelatedWork W2074958815 @default.
• W1917966482 hasRelatedWork W2116924066 @default.
• W1917966482 hasRelatedWork W3149495921 @default.
• W1917966482 hasRelatedWork W2442143939 @default.

• next