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• W1918052238 endingPage "7031" @default.
• W1918052238 startingPage "7018" @default.
• W1918052238 abstract "Abstract The ability of dendritic cells (DC) to regulate Ag-specific immune responses via their influence on T regulatory cells (Treg) may be key to their potential as therapeutic tools or targets for the promotion/restoration of tolerance. In this report, we describe the ability of maturation-resistant, rapamycin (RAPA)-conditioned DC, which are markedly impaired in Foxp3− T cell allostimulatory capacity, to favor the stimulation of murine alloantigen-specific CD4+CD25+Foxp3+ Treg. This was distinct from control DC, especially following CD40 ligation, which potently expanded non-Treg. RAPA-DC-stimulated Treg were superior alloantigen-specific suppressors of T effector responses compared with those stimulated by control DC. Supporting the ability of RAPA to target effector T and B cells, but permit the proliferation and suppressive function of Treg, an infusion of recipient-derived alloantigen-pulsed RAPA-DC followed by a short postoperative course of low-dose RAPA promoted indefinite (&gt;100 day) heart graft survival. This was associated with graft infiltration by CD4+Foxp3+ Treg and the absence of transplant vasculopathy. The adoptive transfer of CD4+ T cells from animals with long-surviving grafts conferred resistance to rejection. These novel findings demonstrate that, whereas maturation resistance does not impair the capacity of RAPA-DC to modulate Treg, it profoundly impairs their ability to expand T effector cells. A demonstration of this mechanism endorses their potential as tolerance-promoting cellular vaccines." @default.
• W1918052238 created "2016-06-24" @default.
• W1918052238 creator A5016218098 @default.
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• W1918052238 creator A5088002190 @default.
• W1918052238 creator A5088600292 @default.
• W1918052238 date "2007-06-01" @default.
• W1918052238 modified "2023-10-14" @default.
• W1918052238 title "Rapamycin-Conditioned Dendritic Cells Are Poor Stimulators of Allogeneic CD4+ T Cells, but Enrich for Antigen-Specific Foxp3+ T Regulatory Cells and Promote Organ Transplant Tolerance" @default.
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• W1918052238 doi "https://doi.org/10.4049/jimmunol.178.11.7018" @default.
• W1918052238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17513751" @default.
• W1918052238 hasPublicationYear "2007" @default.
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