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- W1918071738 abstract "Aims: Modifications of the hyaluronic acid (HA), Hyaluronidases (Hyal), Hyaluronan synthases (HAS), E-cadherin and the transformer growth factor B (TGF-B) may favor invasion, cellular motility and proliferation in lung adenocarcinomas. We examined Hyal1 and 3, HAS1,2 and 3, e-cadherin and TGF-B profile in lung adenocarcinoma (AD) subtypes and squamous cell carcinoma (SqCC) of smokers/nonsmokers. Methods: Fifty-six patients, mean age 64 years, who underwent lobectomy for AD (n=31) and SqCC (n=21) were included in the study. We used immunohistochemistry and morphometry to evaluate Hyal, HAS, e-cadherin and TGF-B expression. Results: SqCC expressed Hyal3 predominant by stromal cells, whereas acinar predominant AD expressed strongly HAS3. In situ, papillary and solid patterns presented a weak expression of the immunomarkers. A positive association was found between smoking history and increased HAS1, HAS3 and Hyal1, while predominant acinar AD were negatively associated to HAS1, HAS3 and Hyal1. The following positive associations were found: TGF-B vs E-cadherin in stroma, TGF-B in tumor vs HAS2. Negative correlation occurred between TGF-B and HAS3 vs Hyal1, TGF-B vs HAS3 and Hyal1. E-cadherin was more frequent in the samples without lymphonode metastasis.Conclusion: A profile of Hyal, HAS, E-cadherin and TGF-B has impact on AD subtypes and SqCC of smokers/nonsmokers, appearing as promise markers to guide treatment options." @default.
- W1918071738 created "2016-06-24" @default.
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- W1918071738 date "2013-09-01" @default.
- W1918071738 modified "2023-09-27" @default.
- W1918071738 title "Hyaluronidase, hyaluronan synthase, E-cadherin and TGF-Β profile in lung adenocarcinoma subtypes and squamous cell carcinoma of smokers/nonsmokers" @default.
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