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• W1918084211 abstract "Cofilin-ADF (actin-depolymerizing factor) is an essential driver of actin-based motility. We discovered two proteins, p65 and p55, that are components of the actin-cofilin complex in a human HEK293 cell extract and identified p55 as CAP1/ASP56, a human homologue of yeast CAP/SRV2(cyclase-associated protein). CAP is a bifunctional protein with an N-terminal domain that binds to Ras-responsive adenylyl cyclase and a C-terminal domain that inhibits actin polymerization. Surprisingly, we found that the N-terminal domain of CAP1, but not the C-terminal domain, is responsible for the interaction with the actin-cofilin complex. The N-terminal domain of CAP1 was also found to accelerate the depolymerization of F-actin at the pointed end,which was further enhanced in the presence of cofilin and/or the C-terminal domain of CAP1. Moreover, CAP1 and its C-terminal domain were observed to facilitate filament elongation at the barbed end and to stimulate ADP-ATP exchange on G-actin, a process that regenerates easily polymerizable G-actin. Although cofilin inhibited the nucleotide exchange on G-actin even in the presence of the C-terminal domain of CAP1, its N-terminal domain relieved this inhibition. Thus, CAP1 plays a key role in speeding up the turnover of actin filaments by effectively recycling cofilin and actin and through its effect on both ends of actin filament." @default.
• W1918084211 created "2016-06-24" @default.
• W1918084211 creator A5039919959 @default.
• W1918084211 creator A5053494748 @default.
• W1918084211 date "2002-04-15" @default.
• W1918084211 modified "2023-10-11" @default.
• W1918084211 title "Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover" @default.
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• W1918084211 cites W1540415460 @default.
• W1918084211 cites W1559194921 @default.
• W1918084211 cites W1574875334 @default.
• W1918084211 cites W1589135618 @default.
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• W1918084211 doi "https://doi.org/10.1242/jcs.115.8.1591" @default.
• W1918084211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11950878" @default.
• W1918084211 hasPublicationYear "2002" @default.
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